Understanding the Value of Clinical Osmometers | Advanced Instruments
We are open and continue to provide essential lab supplies during the COVID-19 pandemic. Answers to your FAQs can be found here. Read More

The Value of Our Clinical Osmometers



Our tradition of high-quality osmometers continues with new advanced features for the current laboratory environment.

The single-sample Osmo1® and multi-sample OsmoPRO® are our most recent and upgraded osmometers. They deliver the high precision and accuracy of previous models but also provide improved ease-of-use and enhanced data management.
Our A2O® Advanced Automated Osmometer further offers the greatest workflow efficiency with complete walkaway testing. Use our library of resources to compare your current model with the features, videos, data, and support options now available with our clinical portfolio of products.

User-Friendly Features

  • Small sample volumes improve test flexibility
  • Flexible user settings increase patient data security and integrity
  • On-board printer and network connectivity enable simpler reporting
  • Automated cleaning on multi-sample instruments reduces hands-on time
  • Primary tube loading on the A2O allows full walk-away testing

Gold Standard Technology

Our osmometers rely on our gold-standard freezing-point depression technology to provide the patient results you’ve come to trust.  

  • Freezing point depression osmolality measurement
  • 2- or 3-point calibration 
  • On-board Levey-Jennings charts

Learn more about our Freezing Point Technology here.

Support Options

Advanced Instruments provides excellent support for your osmolality testing.  We are ready to help you with the seamless integration and validation of your upgraded instrument. 

Learn more about our clinical lab services or contact our Sales team for details.

Resources to Learn More About our Available Models

Fully Automated Osmolality Testing with the A2O®

Learn how Advanced Instruments’ original multi-sample osmometer, the A2O, can fully automate osmolality testing for your lab.

Osmo1® Single-Sample Micro-Osmometer vs. Model 3320 Osmometer

The discontinued Advanced Instruments Model 3320 Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

OsmoPRO® Multi-Sample Micro-Osmometer vs. Model 2020 Osmometer

The discontinued Advanced Instruments Model 2020 Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation multi-sample micro-osmometer, the OsmoPRO, and compare the old with the new.

Osmo1® Single-Sample Micro-Osmometer vs. 3250 Single-Sample Osmometer

The discontinued Advanced Instruments 3250 Single-Sample Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

Osmo1® Single-Sample Micro-Osmometer vs. Fiske 210 Single-Sample Micro-Osmometer

The discontinued Advanced Instruments Fiske 210 Single-Sample Micro-Osmometer has been a trusted instrument in thousands of laboratories around the world. In this short video, we will introduce you to our next-generation single-sample micro-osmometer, the Osmo1, and compare the old with the new.

Clinical Validation Comparison: Osmo1® Single-Sample Micro-Osmometer Versus Model 3250 Single-Sample Osmometer

The Osmo1® Single-Sample Micro-Osmometer is the replacement for the Model 3250 Single-Sample Osmometer which was discontinued in 2020. The Osmo1 provides additional benefits over the Model 3250 including but not limited to a touchscreen display for ease-of-use, integrated barcode scanning, a small 20 µL sample size and the elimination of heat transfer fluid. This paper summarizes a study comparing the performance of the Osmo1 and Model 3250 osmometers. In the study, the Osmo1 exhibited no significant performance difference compared to the Model 3250 and met all acceptance criteria for linearity, precision and accuracy.