Cell-Based Vaccine Production | Advanced Instruments
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Enhanced vaccine development and manufacturing workflows.

Vaccine Production using Mammalian Cells

Stable cell lines are required for industrial production of recombinant protein vaccines. Ensuring that the cell line was derived from a single cell, ‘clonally-derived’, can lead to a more robust cell line. Current best practice with immortalized cell lines producing a vaccine is to perform single-cell isolation. Speed of cell line development is especially important in this case to quickly combat a potential pandemic. With the Solentim workflow, the time from transfection to cell banking can be achieved in as little as 12 weeks.


Osmolality testing is required to ensure that the final vaccine product is safe for administration. The osmolality must be within a physiological range to be introduced in human tissues. There is also evidence that injectable formulations with high osmolality may cause pain at the site of injection.

Vaccines are derived from a variety of sources, both living and synthetic, meaning a variety of bioproduction workflows are required. These workflows include some common use cases for osmolality testing such as cell culture monitoring, buffer media preparation, and final QC.

With the OsmoTECH® portfolio of osmometer you can always ensure product quality throughout every step of vaccine manufacturing.

Accelerating The Timeline to Develop mRNA Based Vaccines

mRNA can be complexed with different agents (e.g. PEI) for delivery within the body. Osmolality impacts the stability of the complex of viral models and the ability to penetrate the target cell membrane.

For the VIPS, there's so little media centered in the well that it makes it easy to locate the cell and prove the health authorities that the cell is clonal.

Thomas Kelly, Scientist at Janssen R&D LLC

Popular Educational Resources

Learn more about how our technologies can be utilized to help accelerate your cell based vaccine production by checking out our educational resources below


Practical Use of Osmolality Measurement in Vaccine Formulation Development


Warp speed RNA vaccine development and manufacturing in the Covid Age: How can we mass produce high-quality vaccines faster and cheaper?


Reliable Osmolality Testing of High Concentration mAb Formulations

Associated Products

OsmoTECH® XT Single-Sample Micro-Osmometer

Best-in-class osmolality performance, designed for the toughest samples

OsmoTECH® PRO Multi-Sample Micro-Osmometer

Combines ease-of-use with accurate and precise measurements for reliable results

Solentim Cell Metric® X

Simplify clonal assurance with Artificial Intelligence

Solentim VIPS® PRO

High efficiency, single cell seeding with image-based proof of clonality for GMP-compatible workflows


Bioprocessing Services

Get the best performance from your osmometers and cell line development instruments from the people who designed and built them. We provide a range of services and service plans to meet the different needs of our customers.

Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your Advanced Instruments products.