OsmoTECH® Single-Sample Micro-Osmometer | AI

OsmoTECH® Single-Sample Micro-Osmometer

Combining ease-of-use with features that streamline compliance with regulatory standards, the OsmoTECH Single-Sample Micro-Osmometer gives biotech and food and beverage labs the insight into their materials and processes to ensure quality while maximizing productivity.

Highlighted features:
  • Single-sample osmometer
  • Direct-draw loading
  • Secure and efficient data management
  • Supports 21 CFR part 11 & EU Annex 11 compliance
  • Meets Pharmacopeia osmolality testing guidelines

Overview

Industry Applications

biotech

IN BIOTECH LABS

Maximize biologic yield, quality, and purity by optimizing and ensuring the quality and consistency of your buffers, media, product, excipients, and process parameters.

food

IN FOOD & BEVERAGE LABS

Maintain efficiency while ensuring product quality and process consistency with osmolality testing from formulation to release.

PRODUCT FEATURES

ONE-STEP DIRECT SAMPLING

Simply aspirate sample and load the sampler in the OsmoTECH. Go-to osmometer for slightly viscous samples.

INTUITIVE TOUCH-SCREEN INTERFACE

The menu-driven operating system, multi-language capability and touchscreen graphic interface all make for easy operation.

SMALL SAMPLE REQUIREMENT

Requiring only 20 µL of sample, the OsmoTECH is ideal for sample-limited applications.

INDUSTRY LEADING ACCURACY AND PRECISION

OsmoTECH utilizes the industry-preferred freezing point depression method to accurately and precisely determine osmolality.

FACTORY CALIBRATED

The system is factory calibrated and ready to test. Recalibration is only required if quality control is out of specification, or after maintenance.

MAINTAIN TRACEABILITY

The integrated barcode scanner simplifies sample identification and reduces transcription errors.

PRESERVE YOUR AUDIT TRAIL

Get a complete time-stamped record of usage, role, and actions requiring reason for settings changes, as well as the unique ability to annotate test results via the handy comments field.

PROTECT YOUR DATA

Active Directory/LDAP options minimize manual input and the risk of errors. Automatic or manual backups, three levels of user access, and an automatic logout timer keep your data safe during idling. Plus you get unlimited results and events storage.

EASILY INTEGRATE DATA MANAGEMENT INTO YOUR ESTABLISHED WORKFLOW

Quickly save data to a network database, USB device, or the embedded Web server and eliminate the need to manually manage date and time by synchronizing with network time.

EXPORT DATA WITH EASE

Move data using Open Protocol Communication (OPC), USB download, Network share, IS (TCP/IP communication), and an Optional DOT-MATRIX PRINTER.

BACKED BY COMPREHENSIVE SUPPORT

You can purchase any Advanced Instruments osmometer with complete confidence as every instrument is backed by a knowledgeable, experienced, and responsive customer support team.

Technical Specifications

Sample typeAqueous-based solution
Sample volume20 ± 1 μL
Test time90 seconds
Sample capacitySingle sample
UnitsmOsm/kg H2O
Resolution1 mOsm/kg H2O
Range0-2000 mOsm/kg H2O
Accuracy20-400 mOsm/kg H2O: mean value ± 2 mOsm/kg H2O from nominal value (1 SD) >400- to <1500 mOsm/kg H2O:≤ 0.5% from nominal value (1 SD) >1500- to 2000 mOsm/kg H2O:≤ 1% from nominal value (1 SD)
Within-run repeatability20-400 mOsm/kg H2O: standard deviation ≤ 2 mOsm/kg H2O >400 to <1500 mOsm/kg H2O: Coefficient of Variation ≤ 0.5% >1500 to <2000 mOsm/kg H2O: Coefficient of Variation ≤ 1%
Temperature effects3< 1 mOsm/kg H2O per 5°C (9°F) ambient temperature change
CommunicationUSB 2.0 Type A Port (2), USB 2.0 Type A Port (1), Ethernet 10/100, RJ45 connector port (1) dot matrix printer (optional)
Supported languagesSimple Chinese, Czech, Danish, Greek, Portuguese, English, French, German, Italian, Japanese, Korean, Russian, Spanish, Turkish
Storage temperature-20°C to +45°C (-4°F to +113°F)
Electrical voltage100 to 240 VAC (50/60 Hz)
Power consumption60 Watts
Dimensions (D x W x H)38 cm x 35 cm x 29 cm (15” x 14” x 11.5”)
Net weight6.0 kg (13.3 lbs.)
Shipping weight11.4 kg (25 lbs.)
WarrantyOne-year limited warranty on workmanship and parts
  1. Subject to change
  2. Accuracy and precision (within run) specifications apply to Advanced Instruments standards
    and reference solutions. Performance at Reference Conditions: 20°C to 25°C (68°F to 77°F);
    40 to 60% relative humidity
  3. Operating Conditions: Temperature 18°C to 35°C (64°F to 95°F); 5 to 80% relative humidity
    (non-condensing)
  4. Dimensions when Micro-Sample Test Kit is on the instrument

Associated Products

Osmometer Calibration Standards

50, 850 & 2000 mOsm
10 x 2mL Ampules

Osmolality Linearity Set

100-2,000 mOsm
5x 2x 5mL Ampules

Osmometer Calibration Standards and Reference Solutions

SK-OsmoTECHConvenience Kit (Includes: TECH250, 3MA005, 3MA029, 3MA085, 3MA200, 3LA028)
3MA029Clinitrol 290 Reference Solution, 10×2 mL AmpulesView
3MA0000 mOsm Calibration Standard, 10x2mLView
3MA00550 mOsm Calibration Standard, 10×2 mLView
3MA085850 mOsm Calibration Standard, 10×2 mLView
3MA2002000mOsm Calibration Standard, 10×2 mL AmpulesView

Supplies

TECH250Micro-Sample Test Kit: 1 boxes of 250 chamber cleaners, 250 sampler tips, 1 plunger wire
3M0828APlunger Wire, 1 per order (Replaces 3M0828- Plunger Wires, set of 2. Please note: A plunger wire is included in every 133800 and TECH250 Micro-Sample Test Kit box.)
3M0825Ease-Eject 20-Microliter Sampler
240821Sampler Tips, 50/pkg

Accessories

135022Epson Dot Matrix Printer (sold-separately)
AN2TP5Dot Matrix Printer Paper

Biotech Services

Get the best performance from your osmometer from the people who designed and built it. We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your osmometers.

Applications

Resources for applications of using osmolality within biotechnology processes and drug manufacturing, plus product quality assurance within food & beverage.

When it comes to process development and manufacturing of protein therapeutics, whether you’re making an antibody-based or other protein therapeutic, what you don’t know can slow you down.

  • Are all of your buffers and media formulated correctly?
  • Does your solution have unexpected components?
  • Are all of the steps involving solutions–i.e. cell growth, dialysis, chromatography–proceeding consistently and as expected?

Osmolality, the measurement of total solute concentration, is a reliable control specification and in-process parameter that can deliver information across the protein therapeutic process development and manufacturing workflow.

Upstream

Optimize cell culture conditions to maximize cell density and yield.

Cell-Line-Development_TItle

Cell Line Development

Ensure that culture conditions are compatible with your clone and cell culture system contributing to optimal cell density and tite.
Media-Preparation_Title

Media Preparation

Check media composition for optimal cell growth.
Cell-CultureMonitoring_Title

Cell Culture Monitoring

Ensure that culture conditions are correct for proper growth and health of cells. This promotes maximum density and yield.
Downstream

Monitor buffer composition and processes, such as chromatography and filtration, to ensure protein purity and yield.

BufferPreparation_Title

Buffer Preparation

Check for proper buffer composition for efficient processing and optimal quality and yield.
Chromatography_Title

Chromatography

Maintain the purity of the drug intermediates and identify and process deviations that could compromise product yield.
Buffer-Exchange_TItle

Buffer Exchange

Monitor buffer composition and verify proper exchange to optimize the number of diavolumes and acquire the highest product yield with the highest quality.
Fill & Finish

Monitor and verify the concentration of API and excipients to meet internal quality and regulatory requirements

FormulationDevelopment_title

Formulation Development

Optimize formulation concentration and stability for high yield in manufacturing.
Final-Formulation_Title

Final Formulation

Monitor and/or verify the concentration of excipients. Confirm soluble content of formulations. Minimize injection site pain.
Filtration_and_Fill_Title

Filtration and Fill

Key compendial release specification to confirm product stability.

References

When the therapeutic you’re developing is cell-based, constant monitoring to optimize growth and ensure consistent culture conditions throughout multiple stages is critical for success.

  • Are your stem cells at highest viability and product quality levels throughout culture and passaging?
  • Are you ensuring a high rate of cell recovery post-thaw?
  • Are your transduction mechanics being optimized?

Using osmolality can help your group answer these questions early in the process, ultimately helping you save time, money, and limited or costly reagents. Adding a simple 90-second osmolality measurement to the in-process parameters you measure is a quick and easy way to ensure optimal cell growth, during process development and manufacturing as well as during buffer and media preparation.

Upstream

Characterize media and optimize transduction of cells with lentivirus to optimize cell viability and size.

Cell-Line-Development_TItle

Cell Line Development

Ensure appropriate trending by monitoring small-scale cell culture for some cell therapies.
Media-Preparation_Title

Media Preparation

Characterize media formulation and QC raw materials for optimal cell growth.
Cell-CultureMonitoring_Title

Cell Culture Monitoring

Ensure that culture conditions are correct for proper growth and health of cells. This promotes maximum cell viability.
Downstream

Optimize downstream processing by confirming buffer concentrations and minimizing shock to cells.

BufferPreparation_Title

Buffer Preparation

Check for proper buffer composition for efficient processing and optimal quality and yield.
Chromatography_Title

Chromatography

Maintain purification conditions to maximize yield and protect cells.
Buffer-Exchange_TItle

Buffer Exchange

Optimize solution concentrations for UF/DF concentration and buffer exchange to acquire the highest product yield with the highest quality.
Fill & Finish

Monitor and ensure final composition and manage cryopreservation and storage.

FormulationDevelopment_title

Formulation Development

Optimize formulation concentration and composition drug safety.
Final-Formulation_Title

Final Formulation

Confirm concentration of formulations and ensure compatibility of cells with cryopreservatives.
Filtration_and_Fill_Title

Formulation and Fill

Key compendial release specification to confirm stability.

Consistency is critical when producing genetic therapies, including viral vector delivery and gene editing.  Small deviations in the composition of cell growth media can have unwanted effects on cell density, cell composition, and virus yield.

  • Are you looking for ways to increase vector stability?
  • Is your gene therapy group looking for higher transfection efficiency and higher viral vector production?

Using osmolality can help your group work towards those goals, as well as answer:

    • how to optimize the physiological range for transfection complexes
    • identifying media needs
    • determining effects of osmotic pressure on the stability of a complex

When done right, osmolality, the measurement of total solute concentration, is a reliable control specification and in-process parameter that can deliver information across the gene therapy process development and manufacturing workflow.

Upstream

Optimize cell culture conditions and media selection to maximize cell density, size and, ultimately, virus yield.

Cell-Line-Development_TItle

Cell Line Development

Ensure that culture conditions are compatible with your clone and cell culture system, contributing to optimal cell density and titer. Maximize transfection efficiency for optimal yield.
Media-Preparation_Title

Media Preparation

Characterize media preparation and composition for optimal cell growth
Cell-CultureMonitoring_Title

Cell Culture Monitoring

Ensure that culture conditions are correct for proper growth and health of cells. This promotes maximum cell density and yield.
Downstream

Check raw material concentration and perform in-process monitoring of purification and filtration steps to maximize purity, cell/virus stability, and yield.

BufferPreparation_Title

Buffer Preparation

Check for proper buffer composition for efficient processing and optimal quality and yield.
Chromatography_Title

Chromatography

Maintain the purity of the drug intermediates, protect the viral vector and genetic content within the vector during process, and identify process deviations that could compromise product yield.
Buffer-Exchange_TItle

Buffer Exchange

Monitor buffer composition and verify proper exchange to optimize the number of diavolumes and acquire the highest product yield with the highest quality.
Fill & Finish

Monitor and ensure final composition, dosage, and stability

FormulationDevelopment_title

Formulation Development

Optimize formulation concentration and composition for high yield in manufacturing.
Final-Formulation_Title

Final Formulation

Monitor and/or verify the concentration of excipients. Confirm soluble content (solute concentrations) of formulations. Ensure compatibility of precious product with cryopreservatives.
Filtration_and_Fill_Title

Filtration and Fill

Key compendial release specification to confirm product dosage specifications.

Ensure optimal product consistency with quick and accurate osmolality measurement using an OsmoTECH Osmometer. Designed to support food and beverage formulation and development efforts, our osmometers help maximize resources and ensure consistent product quality.

References

  1. Wesley, J. Sports Hydration: ‘07. 2006 November 2

Comparison Guide

All models support
  • Pharmacopeia testing guidelines

Workflow Features
Best for labs with daily sample processing needs of:>10/day>10/day1-10/day1-10/day
Sample volume100 µL30 µL20 µL250 µL
Sample introductionAutomated liquid handling sample cup (automated)Sample cupOne-step directSample cup
Operating range (mOsm/kg H2O)0 – 4,0000 – 2,0000 – 2,0000 – 4,000
Test time (seconds)1809090120
Compliance Support Features
Supports 21 CFR Part 11 & EU Annex 11 compliance
Supports Pharmacopeia testing guidelines compliance
Instrument Features
Integrated barcode scanner
Printer
Multi-language touchscreen display
User name & password compatibility
Multi-sample capacity
Automated cleaning between samples
Automated sample pipetting
Temperature control methodDry cooling (No heat transfer fluid)Dry cooling (No heat transfer fluid)Dry cooling (No heat transfer fluid)Heat-transfer fluid
Data Management Features
TCP/IP
USB
Webserver
OPC-UA, Network share,
Database backup
DTE RS-232, Barcode port
Part #A2OOsmoTECHPROOsmoTECH3250
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  1. Sold separately
  2. Printer (dot-matrix) sold separately
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Educational Resources

Brochure

OsmoTECH® Single-Sample Micro-Osmometer

Application Note

Data Integrity & Compliance – what every lab needs to know

Research Paper

Osmolality as a predictor for model-based real-time monitoring of concentration in protein chromatography