OsmoPRO® MAX Automated Osmometer | Advanced Instruments
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Automated Osmometer

Highlighted Features
  • Single click operation
  • Primary tube compatibility
  • LIS connectivity
  • Small footprint

Automated Osmometer

Do more with less. Osmolality testing just got easier.


  • Primary tube sampling (no more plastic sample cups or tips)  
  • Continuous loading of routine and STAT samples – first to market! 
  • Automation in a compact footprint 

The OsmoPRO MAX delivers unprecedented automation, ease of use and efficiency for your lab. With the OsmoPRO MAX, sample pipetting, testing, cleaning, and data transfer are performed automatically by the device. Continuous loading and unloading allows your staff to begin tests as soon as samples come in—load a sample and walk away. High- and low- volume labs alike will benefit from faster turnaround times, improved accuracy through automation, and reduced risk of errors with techs of varying skill levels.  

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Unsurpassed Automation and Ease of Use

Clinical laboratories are under intense pressure to balance the high demand for testing with the desire among clinicians and patients to quickly get accurate results.

Offering unprecedented automation, ease of use, and workflow flexibility, the OsmoPRO MAX is built for labs of all sizes. Features like automated pipetting, continuous loading of primary tubes, onboard video instructions, and integrated barcode scanners minimize errors and simplify the testing process. The instrument takes walk-away osmolality testing to a new level, increasing confidence among your staff and allowing them to focus on other value-added laboratory tasks.


Built For Labs of All Sizes


Simple and intuitive operation eliminates manual processes, minimizes errors, and enables staff of varying skill levels to deliver accurate and timely results.


Effortlessly process any volume of tests and focus on other laboratory priorities with the built-in automation, flexibility, and ease-of-use of the OsmoPRO MAX.


Automated, continuous testing and cleaning streamlines high throughput testing with minimal user intervention.

Product Features


The OsmoPRO MAX automatically pipettes a sample directly from the primary tube and performs testing and cleaning within the device, eliminating the need for consumables.


The OsmoPRO MAX turntable allows users to continuously load and unload samples in a variety of primary tube sizes, preventing workflow interruptions and improving turnaround times.


Walk away while the OsmoPRO MAX performs testing of replicates from the same primary tube.


Calibration is needed as infrequently as once per year and the instrument is designed to be powered on 24/7 to maximize uptime.


A color-coded touchscreen, intuitive user interface and multi-language capability enable staff of varying skill levels to operate the device. Onboard video instruction guides users through cleaning, maintenance, and calibration workflows.


An integrated barcode scanner automatically scans the turntable to determine the number of samples present and their sample IDs.


The liquid handling system automatically detects the level of the sample in the primary tube. Ready-to-use system fluid automates cleaning between samples for up to 500 tests.


Automatically upload data to the AdvancedQC™ Peer Group Program to compare results with peers and spot changes in instrument performance. Lock-out capability enables supervisors to require passing QC before sample testing.


Easily export data to your laboratory information system, a USB, or an optional printer. Two-level user access with supervisor-defined permissions provides peace of mind, and sample IDs, password-protected user IDs, and lot recording enable traceability.


A second integrated barcode scanner scans employee badges as well as calibration and controls kits for user and lot traceability.

Technical Specifications

Sample type Serum, plasma, urine
Measurement Principle Freezing point depression
Minimum Required Sample Volume 170 μL
Test time ~3 minutes
Sample Capacity Continuous loading of up to 500 samples
Resolution 1 mOsm/kg H2O
Range 0 to 2000 mOsm/kg H2O
Accuracy2 Mean value ±2 mOsm/kg H2O from nominal value between 0 and 400 mOsm/kg H2O (1 SD)
Mean value ± 0.5% from nominal value between 400 and 1500 mOsm/kg H2O (1 SD)
Mean value ±0.75% from nominal value between 1500 to 2000 mOsm/kg H2O (1 SD)
Precision2 Standard deviation ≤2 mOsm/kg H2O between 0 and 400 mOsmo/kg H2O
Coefficient of variation ≤0.5% mOsm/kg H2O between 400 to 1500 mOsm/kg H2O
Coefficient of variation ≤0.75% mOsm/kg H2O between 1500 to 2000 mOsm/kg H2O
Display Touchscreen with onboard video instructions
Memory capacity 1,000 results / 10,000 events
Temperature effects3 Less than 1 mOsm/kg H2O per 5°C (9°F) ambient temperature change
Supported Languages Chinese, Czech, Danish, Dutch, English, French, German, Italian, Japanese, Korean, Portuguese, Spanish, Swedish
Communication USB 2.0 Type A ports (3)
USB 2.0 Type B port (1)
Ethernet 10/100
RJ45 connector port (1)
Printer (optional)
Storage temperature -40°C to +45°C (-40°F to +113°F)
Electrical voltage 100 to 240 VAC (50/60 Hz)
Power consumption 60 Watts
Dimensions (D x W x H) 14.0” (36 cm) W x 16.5” (42 cm) D x 18” (46 cm) H
Net weight 13.5 kg (30 lb)
Shipping weight 20.9 kg (46 lb)
Warranty One-year limited warranty on workmanship and parts
  1. Subject to change
  2. Accuracy and precision (within run) specifications apply to Advanced Instruments standards and reference solutions. Performance at Reference Conditions: 20°C to 25°C (68°F to 77°F); minimum of 30% relative humidity
  3. Operating Conditions: Temperature 18°C to 35°C (64°F to 95°F); 5 to 80% relative humidity (non-condensing)

Associated Products

Osmometer Calibration Standards and Reference Solutions

3MA552OsmoPRO MAX Calibration Set
3MA002Osmolality Linearity Set, 2mL View
3MA029Clinitrol™ 290 Reference Solution, 10×2 mL ampulesView

Osmometer Control Solutions

3MA028Protinol 3-Level Osmometer Control 3x3x3 mLView
3LA085Renol 2-Level Osmometer Control 2x4x3 mLView

Supplies & Accessories

MAX500OsmoPRO MAX Maintenance Kit
552923OsmoPRO MAX Small Volume Inserts, package of 100
552921OsmoPRO MAX Tubes, package of 250
Osmolality Linearity Set

0, 500, 900, 1500, 2000 mOsm/kg H2O 5x 2x 2mL Ampules

View Product
Protinol™ Protein-Based Controls & Renol™ Urine Based Controls

Protinol 3-Level Osmometer Control 3x3x3 mL Renol 2-Level Osmometer Control 2x4x3 mL

Learn more



Medical lab instruments that deliver accuracy and efficiency

Across clinical laboratories, there’s a need to alleviate high workloads and boost efficiency while delivering rapid, accurate osmolality test results.

Advanced Instruments portfolio of osmometers meets your need for ease of use, efficiency and reliability. Backed by more than 65 years of industry-leading performance, our instruments deliver the automation, workflow flexibility, and data management and security you need to get more done in less time.

Keep your labs running smoothly and in compliance with osmometers that use the industry preferred freezing point depression method to provide accurate patient results.

Related Products

Comparison Guide

All models support compliance with accreditation bodies

Workflow Optimizations
Integrated barcode scanner
Multi-language touchscreen display
Multi-sample capability
Automatic cleaning between samples
Automatic testing
STAT testing & load more capability
Continuous loading and unloading
Programmable replicate testing
Badge scanning capability
Automatic sample identification
Primary tube testing
Onboard video instructions
Quality Control Features
Out of specification QC alert capability
Real-time QC status indicator
Primary vial control testing*
Data Traceability, Security and Flexibility
Sample ID traceability
User traceability
Two-level, password protected user access
Onboard results & events storage
Ethernet for LIS connectivity
Multiple USB connections
Minimum sample volume 150 µL 20 µL 20 µL
Osmolality test method Freezing point depression Freezing point depression Freezing point depression
Size (w/d, cm) 36 x 42 25 x 38 36 x 38
Part # OsmoPRO MAX OsmoPRO Osmo1

*With AI-branded controls
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Educational Resources

Application Note

Osmolality: A Crucial Medical Tool for a Vast Range of Use Cases

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Application Note

Tackling Staff Shortages by Optimizing the Testing Workflow

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Application Note

Clinical Osmometers: Meeting the Increasing Need for Workflow Efficiency

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