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Osmolality Analysis in Bioprocessing: From Theory to Practice, Upcoming Webinar Hosted by Xtalks

November 6, 2023

In this free webinar, gain insights into the role of monitoring osmolality in bioprocessing research. Attendees will learn about using osmolality analysis in Chinese hamster ovary (CHO) cell health studies. The featured speakers will discuss current uses and future potential for osmolality analysis at the upstream and downstream stages of bioprocessing.

TORONTO, Nov. 6, 2023 /PRNewswire-PRWeb/ — Discover an informative webinar exploring the impact of osmolality in bioprocessing and in correlation with immunoglobulin G (IgG) production. Osmolality is described as the measurement of the contribution of all the dissolved solutes to the osmotic pressure of a solution. In biopharma, osmolality is usually used as a critical quality control (QC) check for cell culture media, buffers and formulated drug products. It is also used as a critical process parameter during upstream cell culture and downstream filtration.

The Cell Technology group at the National Institute for Bioprocessing Research and Training (NIBRT) focuses on the development of bioprocesses using mammalian cells to produce recombinant proteins, monoclonal antibodies and viral vaccines. There is also a particular interest in the bioprocess conditions that can be used to control the biochemical structure and the post-translational modifications of glycoproteins and hence the quality of biopharmaceuticals.

Osmolality is routinely used in the Cell Technology group as a QC tool, similar to the routine application in the biopharma industry. However, osmolality is applied as an experimental measurement to correlate with IgG production, nutrient depletion studies and bioprocessing applications.

In this webinar, the featured speaker will describe the impact of osmolality assessment in correlation with IgG production when examining the effect of plant protein hydrolysates as additives, in a media development project. When examining the effect of changing media composition to affect IgG glycosylation, osmolality was tracked and correlated with growth and productivity.

In the investigation into the recoverability of cells at various stages of nutrient depletion, osmolality measurements were utilized to correlate the suitability of culture conditions in ‘re-fed’ media, vs. controls of complete media. These preliminary investigations are in the process of being scaled up to the bioreactor level (bench scale) where osmolality validation will be used on samples taken in at-line process analytical technology (PAT) instrumentation development.

Join this webinar to gain insights into osmolality in correlation with IgG production in a media development project.

Join Dr. James Flynn, Research Scientist, National Institute for Bioprocessing Research and Training (NIBRT); and Kendal Studd, Field Application Specialist, Advanced Instruments, for the live webinar on Friday, November 17, 2023, at 11am EST (4pm GMT/UK).

For more information, or to register for this event, visit Osmolality Analysis in Bioprocessing: From Theory to Practice.


Xtalks, powered by Honeycomb Worldwide Inc., is a leading provider of educational webinars to the global life science, food and medical device community. Every year, thousands of industry practitioners (from life science, food and medical device companies, private & academic research institutions, healthcare centers, etc.) turn to Xtalks for access to quality content. Xtalks helps Life Science professionals stay current with industry developments, trends and regulations. Xtalks webinars also provide perspectives on key issues from top industry thought leaders and service providers.

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