East Coast User Group Meeting | Advanced instruments
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East Coast User Group Meeting

The Solentim Cell Line Development User Group Meeting is free to attend and is organised by Advanced Instruments for anyone interested in learning about the latest developments and technologies in the cell line development (CLD) space.

Join us on Tuesday, October 25th 2022, at the MassBio Hub in Cambridge, MA, and virtually to hear from users presenting their experiences. Additionally, hear about our latest technology for single-cell seeding, the NEW VIPS PRO. Perhaps most importantly, it’s a chance to interact with your peers within the cell line development field.

Presentations

Moderator

Round Table Moderator: Mike Brem, Director of Cell Line Development

Company: Wheeler Bio

Bio: Mike Brem is the Director of Cell Line Development at Wheeler Bio in Oklahoma City.  He is an accomplished cell biologist and protein scientist with over 23 years of industry experience in the biologics arena.  His technical expertise is centered on therapeutic protein production, host cell engineering and stable cell line development in both small and large pharma environments.   Mike’s long track record (over 100 stable cell lines) is connected to an extensive list of successful clinical milestones for biological products.  He has worked with an extensive list of host cells to express monoclonal antibodies, bispecific and fragment antibodies, fusion proteins, enzymes, vaccines, cytokines and advanced therapies like AAV and other viral vectors.  One of Mike’s most impactful projects was the generation of the stable cell lines for Myozyme® and Lumizyme® approved by the FDA (2006 and 2010, respectively) for the treatment of Pompe Disease (Sanofi Genzyme).  His current responsibilities are focused on the build out of Wheeler’s cell line development laboratories and platform manufacturing technology (ECHO2™).  He also led the integration of ECHO2™ in the Wheeler East location in Waltham, MA.  Mike holds a bachelor’s degree in Biology (with minors in Math, Chemistry and Music) from East Central University in Ada, OK and is a regular contributor and speaker at industry conferences.

Mike Brem headshot

Improving CHOZN® cell lines and workflows using the Cell Metric

Speaker: Amber Petersen,  R&D Manager –  Biopharmaceutical Expressions Systems Team

Company: MilliporeSigma

Bio: Amber is an R&D Manager in the Biopharmaceutical Expressions Systems Team at MilliporeSigma, based in St. Louis, MO. Amber leads technology evaluations and R&D projects using genetic engineering and other approaches to improve cell line development workflows and host cell lines for biomanufacturing. Before joining MilliporeSigma in 2015, Amber earned a Ph.D. in Neurobiology, Cell Biology, and Anatomy from the Medical College of Wisconsin in Milwaukee.

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Increased Efficiency of Clonal Selection and CLD workflow with Solentim ICON

Speaker: Kayla Bean, R&D Senior Scientist for Cell Line Development,

Company: AGC Biologics

Bio: Kayla is currently the R&D Senior Scientist for Cell Line Development at AGC Biologics focusing on new technology and platform optimization. Kayla earned her MS and PhD from Georgia State University in Applied and Environmental Microbiology. 

kbean2

Workflow Development for Generating Clinical Gene Edited iPSC Lines 

Speaker: Julie Bershadsky, Scientist II

Company: Notch Therapeutics Inc

Bio: Prior to entering industry, Julia earned her Ph.D. in cancer research from the University of Toronto, where she discovered novel regulators of the Notch signaling pathway in breast cancer. In her current role as a Scientist II Cell Line Development at Notch Therapeutics Inc., Julia is leading the process development activities for the clinical manufacturing of edited iPSC lines. 

Julia Bershadsky

Improving Workflow for GMP Cell Line Development in CDMOs

Speaker: Sakthi Moorthy, Lead Scientist-II 

Company: CCRM

Bio: Sakthi Moorthy is a Lead Scientist-II at CCRM. Before joining CCRM in 2021, Sakthi earned her PhD at Anna University Chennai, India. Sakthi brings more than 5 years of research experience in applying CRISPR technology to generate genome-engineered cell lines from her postdoctoral fellowship at the University of Toronto.

SMoorthy picture

Implementing automated single cell seeding with the VIPS for Cell Line Development 

Speaker: Colleen Patterson, Scientist II

Company: Celldex

Bio: Colleen earned her bachelor of science in biology from Rutgers University. Her current role is a Scientist II at Celldex, which develops targeted antibody therapeutics to address devastating diseases.  

Colleen Patterson

Agenda

8:30 am – 9:00 am: Gather and breakfast

9:00 am – 9:15 am: Opening & welcome

9:15 am – 9:45 am: Andrea Gough, Associate Director Biopharma Reagents, Advanced Instruments- “Advanced Instruments Cell Line Development Ecosystem Overview”

9:45 am – 10:30 am: Amber Petersen, R&D Manager, MilliporeSigma- “Improving CHOZN® cell lines and workflows using the Cell Metric”

10:30 am – 10:45 am: Coffee break

10:45 am – 11:15 am: Kayla Bean, R&D Senior Scientist for Cell Line Development, AGC Biologics – ”Increased Efficiency of Clonal Selection and CLD workflow with Solentim ICON”

11:30 am – 12:00 pm: Benjamin Duckless, Field Application Scientist, Advanced Instruments- “ICON & STUDIUS Overview/Demo”

12:00pm – 1:00pm: Lunch

1:00 pm – 1:30 pm: Andrea Gough, Associate Director Biopharma Reagents, Advanced Instruments- “Introducing New VIPS PRO for iPSC Workflows”

1:30 pm – 2:00 pm: Julia Bershadsky, Scientist II, Notch Therapeutics Inc– “Workflow Development for Generating Clinical Gene Edited iPSC Lines

2:00 pm – 2:30 pm: Sakthi Moorthy, Lead Scientist-II, CCRM- ”Improving Workflow for GMP Cell Line Development in CDMOs”

2:30 pm – 2:45 pm: Break

2:45 pm – 3:15 pm: Colleen Patterson, Scientist II, Celldex – ”Implementing automated single cell seeding with the VIPS for Cell Line Development”

3:15 pm – 3:45 pm: Benjamin Duckless, Field Application Scientist, Camilla Domeneghetti Biology Manager-Cell Line Development, Advanced Instruments- ” Advanced Instrument Cell Line Development Technologies, An Applications Perspective”

3:45 pm – 5:00 pm: Round table moderated by Mike Brem, Wheeler Bio-“Future trends and challenges for Cell Line Development”

5:00 pm: Close of user group

5:00 pm: Happy hour at Cambridge Brewing Company