Improving Titer, Quality and Efficiency of AAV Manufacturing and Production by Optimizing Osmolality

Home
Improving Titer, Quality and Efficiency of AAV Manufacturing and Production by Optimizing Osmolality

Improving Titer, Quality and Efficiency of AAV Manufacturing and Production by Optimizing Osmolality

The study presented here, undertaken by Cell and Gene Therapy Catapult, provides preliminary evidence for impact on overall yield, and quality of the adeno-associated virus 1 (AAV) due to a timed osmolality shift with and without a feeding step.

Osmolality, a measure of solute concentration, can have many applications throughout the entirety of the cell and gene therapy process. There is now clear evidence to show how the manipulation of this critical process parameter can improve overall outcomes.

How Can Osmometers Help in The Bioprocessing Workflow?

Biopharmaceutical labs using routine osmolality testing can have confidence in their processes during the development and manufacturing of biologic drugs while also having better control over the titer, yield, quality, and purity of their product. Learn more about biotech applications of osmolality here.

OsmoTECH^® HT Automated Micro-Osmometer Learn more

OsmoTECH^® PRO Multi-Sample Micro-Osmometer Learn more

OsmoTECH^® XT Single-Sample Micro-Osmometer Learn more

Why Are Advanced Instruments Osmometers The Best Fit For The Biotech Industry?

Trusted and Reliable performance

Over 65 years of experience in developing and manufacturing freezing point depression technology across the biopharmaceutical market. The OsmoTECH portfolio of osmometers offers superior performance across a diverse range of samples, osmolalities, and applications.

Robust Data compliance & management

Data integrity is paramount to ensuring the validity of the data and its analyses. Advanced Instruments osmometers help allow customers to meet the strict data integrity requirements of 21 CFR part 11 and EU Annex 11.

Scalable and Easy to integrate

The bioprocessing workflow is complex and multifaceted, which leads to a varying set of requirements depending on the stage where a customer is located. Designed in close collaboration with customers, the OsmoTECH portfolio of osmometers perfectly meets their requirements and can be easily integrated into the workflow to get their lab ready to go.

Comprehensive & Expert Service offerings

We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, validation, training and maintenance of your osmometers to avoid disruptions to your valuable work.