What Is Osmolality? | Advanced instruments
We are open and continue to provide essential lab supplies during the COVID-19 pandemic. Answers to your FAQs can be found here. Read More

What Is Osmolality?

Osmolality is a valuable measurement tool

Osmolality is the concentration of particles (solutes) dissolved in a solution. You can test the osmolality of many solutions, including serum, urine, plasma, and biologics. You use a special device called an osmometer to test osmolality.

Clinical labs test osmolality of serum, plasma, and urine because it provides information on the body’s hydration state. Measuring osmolality is critical when you suspect toxin ingestion, electrolyte disorders, and metabolic acidosis. Osmolality testing as an initial screening can help reduce cost and improve quality of care.[1]

Biopharmaceutical labs use osmolality testing as an in-process control and quality-check throughout development and manufacture of biologics. Osmolality testing helps ensure cell health, in-process reagent quality, and helps reduce the risk batch failures.

Our world-class osmometers deliver trusted results

Our osmometers use freezing point depression — the gold standard method for testing osmolality throughout the world. Other tests, including specific gravity; refractive index; and conductivity do not provide a complete view of a sample. Only freezing point osmolality is truly independent from the size, ionization status, shape, and other physical characteristics of the liquid solutions.

Osmometer controls you can trust

Our world-class osmometers help clinical labs report accurate and precise patient results and biopharmaceutical labs develop quality therapeutics. That’s why we developed custom calibration controls designed specifically for your osmometer so you get guaranteed performance:

  • Clinically-relevant formulas provide important reference points.
  • Tight tolerances let you quickly spot shifts in performance.
  • Meet CAP and CLIA guidelines to help you comply with regulations.
  • Premixed and ready-to-use: no thawing, adding water, or worrying about mixing errors.

[1]The Value of Osmolality Testing; Neville R. Dossabhoy, MD, FACP, FASN, Consultant Nephrologist


Interested in Advanced Instruments’ Osmometers? Click here to learn more.