4250 Single-Sample Cryoscope | Advanced Instruments
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4250 Single-Sample Cryoscope

Highlighted Features
  • Low maintenance
  • On-board printer for better traceability
  • Rapid & stable automated calibration

4250 Single-Sample Cryoscope

The Advanced Instruments Model 4250 Single-Sample Cryoscope is the fastest, most reliable, and precise system for milk analysis. The Model 4250 employs the industry preferred freezing point depression (FPD) method for determination of added water to milk. The Model 4250 allows your plant to manage a premium milk supply, ensure quality products and improve your operating efficiency.



The 4250 offers both the International Reference Method of Plateau Seeking (ISO/FDIS-5764/IDF 108) and standard timed plateau methods and it operates in both accepted temperature scales millidegrees Celsius (m°C) and millidegrees Horvett (m°H)


Low maintenance; the sample probe and stir-wire are fully accessible for easy cleaning


Optional barcode scanner to input the supplier ID numbers.
On-board printer for better traceability, tracking and to meet your HACCP requirements and RS-232 communication capability for data transfer


The instrument display can be switched between multiple languages


Rapid and stable automated calibration procedure and two minute test time allows for high throughput of samples


Advanced Instruments calibrators, controls and supplies meet the exacting standard required to fulfill ISO, HACCP and QA/QC laboratories

Technical Specifications

Sample volume 2.0 or 2.5 ml
Test time approximately 90 seconds in the 30-second timed mode
Sample capacity Single sample
Unit -m°C or -m°H
Range 0 to 1000 m°C or m°H
communication On boardprinter DTERS-232serialport and optional barcode scanner
Performance at Reference Conditions1
Linearity Less Than ±5% from a straight line
Repeatability ±2 m°C or m°H (1 S.D)
Drift Less Than 1 m°C or m°H per month
Performance Over Operating Conditions
Temperature Effects3 Less than 1 m°C or m°H per 5°C (9°F)ambient temperature change
Operating Conditions
Temperature 18 to 35°C (64 to 95°F)
Humidity 5 to 80% relative humidity (non-condensing)
Storage Temperature -40°C to +45°C (-40°F to +113°F)
Voltage 100 to 240 VAC (50/60 Hz)
Power consumption 95 Watts
Dimensions 16.0″ H x 13.0″W x 18.0″D (40.6cm x 33. 0 cm x 45.7 cm)
Net weight 28.0 lbs. (12.7 kg)
Shipping weight 30 lbs. (17.7 kg)
Warranty One-year limited warranty on workmanship and all parts except glass, Plastic, and part warranted by their makers
Installation Class I
Over-voltage Category II
Pollution Degree 2
Moisture protection IPXO (ordinary)

Associated Products

Controls/Calibrators Aqueous Ampules

3LA022422 Cryoscope Calibration Standard, Bottle 110mLView
3LA023422 Cryoscope Calibration Standard, Ampule 10mLView
3LA027Lactrol 530 Reference Solution, Bottle 110mLView
3LA030Lactrol 530 Reference Solution, Ampule 10mLView
3LA032621 Cryoscope Calibration Standard, Bottle 110mLView
3LA033621 Cryoscope Calibration Standard, Ampule 10mLView

Supplies & Accessories

SK-4250Convenience Kit (Includes: 3LA823, 3DA811, 3LA030, 3LA023, 3LA033, FLA835)
3DA811Heat Transfer Fluid, 1×150 mL
3D2340Air Filters, Disposable, 6/pkg
330016Bar Code Scanner
FLA835Thermal Printer Paper, 5 rolls


3LA823Sample Tube- Glass 2.0 mL

Educational Resources


4250 Single-Sample Cryoscope

Application Note

Monitoring Lactose Hydrolysis in Milk and Milk Products with Cryoscopy


The Effects of Raw Milk Storage Conditions on Freezing Point, pH, and Impedance