4250 Single-Sample Cryoscope | Advanced Instruments
4250 Cryoscope 1
4250 Cryoscope 2
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4250 Single-Sample Cryoscope

The Advanced Instruments Model 4250 Single-Sample Cryoscope is the fastest, most reliable, and precise system for milk analysis. The Model 4250 employs the industry preferred freezing point depression (FPD) method for determination of added water to milk. The Model 4250 allows your plant to manage a premium milk supply, ensure quality products and improve your operating efficiency.

Highlighted features:
  • Low maintenance
  • On-board printer for better traceability
  • Rapid & stable automated calibration



The 4250 offers both the International Reference Method of Plateau Seeking (ISO/FDIS-5764/IDF 108) and standard timed plateau methods and it operates in both accepted temperature scales millidegrees Celsius (m°C) and millidegrees Horvett (m°H)


Low maintenance; the sample probe and stir-wire are fully accessible for easy cleaning


Optional barcode scanner to input the supplier ID numbers.
On-board printer for better traceability, tracking and to meet your HACCP requirements and RS-232 communication capability for data transfer


The instrument display can be switched between multiple languages


Rapid and stable automated calibration procedure and two minute test time allows for high throughput of samples


Advanced Instruments calibrators, controls and supplies meet the exacting standard required to fulfill ISO, HACCP and QA/QC laboratories

Technical Specs

Sample volume 2.0 or 2.5 ml
Test time approximately 90 seconds in the 30-second timed mode
Sample capacity Single sample
Unit -m°C or -m°H
Range 0 to 1000 m°C or m°H
communication On boardprinter DTERS-232serialport and optional barcode scanner
Performance at Reference Conditions1
Linearity Less Than ±5% from a straight line
Repeatability ±2 m°C or m°H (1 S.D)
Drift Less Than 1 m°C or m°H per month
Performance Over Operating Conditions
Temperature Effects3 Less than 1 m°C or m°H per 5°C (9°F)ambient temperature change
Operating Conditions
Temperature 18 to 35°C (64 to 95°F)
Humidity 5 to 80% relative humidity (non-condensing)
Storage Temperature -40°C to +45°C (-40°F to +113°F)
Voltage 100 to 240 VAC (50/60 Hz)
Power consumption 95 Watts
Dimensions 16.0″ H x 13.0″W x 18.0″D (40.6cm x 33. 0 cm x 45.7 cm)
Net weight 28.0 lbs. (12.7 kg)
Shipping weight 30 lbs. (17.7 kg)
Warranty One-year limited warranty on workmanship and all parts except glass, Plastic, and part warranted by their makers
Installation Class I
Over-voltage Category II
Pollution Degree 2
Moisture protection IPXO (ordinary)

Associated Products

Controls/Calibrators Aqueous Ampules

3LA022 422 Cryoscope Calibration Standard, Bottle 110mL View
3LA023 422 Cryoscope Calibration Standard, Ampule 10mL View
3LA027 Lactrol 530 Reference Solution, Bottle 110mL View
3LA030 Lactrol 530 Reference Solution, Ampule 10mL View
3LA032 621 Cryoscope Calibration Standard, Bottle 110mL View
3LA033 621 Cryoscope Calibration Standard, Ampule 10mL View

Supplies & Accessories

SK-4250 Convenience Kit (Includes: 3LA823, 3DA811, 3LA030, 3LA023, 3LA033, FLA835)
3DA811 Heat Transfer Fluid, 1×150 mL
3D2340 Air Filters, Disposable, 6/pkg
330016 Bar Code Scanner
FLA835 Thermal Printer Paper, 5 rolls


3LA823 Sample Tube- Glass 2.0 mL

Installation and Training

Expert installation and training, available only from Advanced Instruments.

Advanced Care Service Agreements

Get total peace of mind with a service agreement—to ensure protection in case of instrument down time.

Educational Resources


4250 Single-Sample Cryoscope

Application Note

Monitoring Lactose Hydrolysis in Milk and Milk Products with Cryoscopy


The Effects of Raw Milk Storage Conditions on Freezing Point, pH, and Impedance

We are open and continue to provide essential lab supplies during the COVID-19 pandemic. Answers to your FAQ’s can be found here.

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