Combined Titer & Cell Viability Analysis | Advanced Instruments

Combined Titer, Cell Viability and Productivity

Streamlining ranking and selection of productive clones

After the static plate stage, clones are adapted for suspension culture and progress through different formats (e.g. 48 and 24 DW plates, spin tubes and shake flasks).

ICON can uniquely triage clones via low volume titer and viable cell assays on one instrument and combines results with confluence and clonality data from Cell Metric® and/or VIPS™ within STUDIUS.

InstiSHAKE™ growth supplements help static clones to transition into deep well suspension cultures.

Explore All Titer and Cell Viability Products

Solentim ICON™

Combined Human IgG1 Titer, VCD and Productivity Analyzer

The ICON with integrated STUDIUS data management platform enables scientists in the biotherapeutic development industry to digitally transform their process and make informed decisions quicker, earlier, and more securely.

Solentim STUDIUS™

The Smartest Decision-Making Platform in Cell Line Development

The STUDIUS powered ecosystem from Advanced Instruments provides a more consistent cell line development workflow for scientists creating biotherapeutic Master Cell Banks, enabling faster and more confident decision making.

Cell Growth Reagents

Designed to work with VIPS automation, Cell Metric imaging, ICON cell analysis, and manual cell growth processes, the Insti Reagents transform workflows and greatly enhance the number of successful colonies per plate, conferring major growth and survival advantages.

They are proprietary animal component-free cell culture supplements for CHO and HEK cells that enhance growth at multiple points in the cell development cycle, including early cell growth and single cell survival, during the transition to deep-well plates, and to protect cells during freezing and thawing.


A Data-Driven Workflow for Cell Line Development

Learn how ICON and STUDIUS can enhance and accelerate your cell line development projects.

How do the ICON titer assay plates work?

The titer plates are coated with Protein G which binds to the Fc portion of IgG molecules.

How long does ICON take to perform a cell count?

The ICON can complete 24 cell counts in under 4 minutes.

What’s the benefit of ICON compared to current methods for viability and productivity

  • Combining viability and titer in one instrument saves bench-space and cost
  • Low volume assays allow scientists to make clone selection decisions earlier
  • Faster and more accurate titer measurements

How will STUDIUS help me manage my cell line development?

By providing consistency across the entire cell line development workflow from seeding to clone selection

  • Elimination of human error in the analysis and interpretation of clonality, titer and viability results
  • Tracking of clones across the cell line development process from seeding to selection
  • Reduction of analysis time related to clone selection from days to minutes