Clinical Compliance & Conformity

Supporting clinical labs in meeting quality standards and regulations

Helping labs globally to meet regulatory guidelines and ensure data security

Clinical labs are under scrutiny to meet quality regulations and standards to ensure accuracy, quality, reliability and compliant reporting of laboratory testing. We understand the need to comply with the highest quality standards and ensure patient data security. That’s why we provide cutting-edge technology and a wide range of support services from our AdvancedQC™ peer group program to secure data transmission to the LIS. Whether your lab is accredited by CAP in the United States, UKAS in the United Kingdom, COFRAC in France, or another accreditation service, we can help you deliver patient results quickly and securely while maintaining compliance.

Supporting compliance with ISO standards

Our products—from our matrix-based osmolality controls to our Artel liquid handling calibration and verification—are designed to help clinical laboratories comply with accreditation and quality systems requirements in support of national regulations. For example, ISO 15189:2022 specifies requirements for quality and competence for medical laboratories. Our Artel portfolio of products, services, and trainings can assist laboratories accredited to this standard in fulfilling requirements related to calibration and verification of pipettes and automated liquid handling systems, as well as training and competence assessments of pipette operators.

Calibrations and routine tests are a necessity to ensure continued data quality and consistent assay performance. Definitions, requirements and acceptable methods for measuring the volumetric performance, including dual-dye ratiometric photometry, are described in ISO 8655 Parts 7 & 8, as well as ASTM E1154 for manually-operated liquid handling devices, and ISO 23783 Part 2 for automated liquid handlers. Our liquid handling liquid handling calibration and verification products, services, and trainings can help you conform to all liquid handling quality requirements.

Popular Educational Resources

Learn more by checking out our educational resources below

Clinical Case Study

Keeping Plasma Safe: Haematologic Technologies Inc. Implements the Artel PCS for Quality Assurance


Clinical Case Study

The Impact of Pipetting Technique Training: On-the-Job Training That’s Not on the Job


Clinical Case Study

Clinical Reference Laboratory (CRL) When “every sample is a life trusted to our care”


Clinical App Note

TRANSCRIPT: A Conversation with the CAP on Osmometer Quality Control


Clinical App Note

Evaluation of Commercially Available Osmometer Control Solutions


Clinical App Note

Evaluation of Forward & Reverse Mode Liquid Handling Techniques


Clinical Webinar

New and Revised ISO Standards


Clinical Webinar

Patient CSF Cell Counts: How to Improve Accuracy and Save Time


Clinical Webinar

Panel Discussion: ISO Standards, Calibrations, and Routine Tests for Liquid Handling Instruments


Clinical Posters

Shining Renewed Light on a Tried-and-True Test: The Critical Role of Osmolality Testing in Improving Health and Economic Outcomes in Patients with Hyponatremia


Clinical Posters

Troubleshooting Automation


Clinical Posters

A Shift From Manual to Automatic: CSF Cell Counts With the GloCyte® Automated Cell Counter System


Clinical Knowledge Center

Importance of Measured Osmolality


Clinical Knowledge Center

The Importance of Calibration


Clinical Knowledge Center

Ratiometric Photometry Technology


Associated Products

Support, Maintenance, and Validation Services

Get the best performance from your instruments from the people who designed and built them. We provide a range of services and service plans to meet the different needs of our customers.

Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your equipment. They have been trained to operate within a regulated environment and are equipped to support you in meeting quality standards.

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[The Anoxomat is] very easy to use and efficient, easy to clean and reliable, it was such an improvement from our previous method of heat sealing and anaerobic pouches, I absolutely love these jars!

Magdalena Margiotta


The MVS [has] made verifications so much more efficient. It also enabled us to detect an issue with one of our instrument onboard pipetting devices. The customer service is great and using this system makes accreditation assessments much easier!

Beth Johnson

KY Division of Lab Services, DPH

[Protinol and Renol produce] great results with the analyzer we use. Excellent quality and easy to use.

Audra Wilson

Meadows Regional Medical Center

The [GloCyte] is easy to operate and user friendly. Quick and accurate results. [...] Steps are easy to remember. Counts RBC’s less than 1000 [...]. Easier to use than using the hemocytometer. NO MORE extra steps seen on using chamber counts: cleaning counting chamber and cover slip before counting, placing chamber in a moist box to wait for cells to settle, lysing RBC with acetic acid before WBC can be counted, focusing microscope etc.

Rodel Rosales

Boston Children's Hospital Core Laboratory

The [Osmo1] is a valuable tool within our facility. The set up was extremely easy. There are a lot of features for programming if you require passwords for individual users or if you just want any lab personnel to be able to run a sample. ... . Maintenance is easy to perform, it is not time consuming, or something you need to dig out the manual for complex instructions. The supply pack has a sensor in it so when consumables need to be replaced it will auto-update the supplies and alert when supplies are >50...

Judy McCormick

Meno Ya Win Hospital

I have set up and trained fellow employees on how to use the PCS Pipette Calibration system over all of our laboratory departments and three hospitals. It is easy to use and understand how to use it in step-by-step instructions while calibrating and setting up pipettes for calibrations.

Angela Achneider

Consultants Laboratory, Agnesian Healthcare

The PCS Pipette Calibrations system is easy to use. The Artel Calibration Standard set is customizable to your set of pipettes. Their service team works hard to match the kit to individual site needs. Capable of calibrating single and multichannel pipettes.

Kathryn Traughber

Tri Cities Laboratory

The Artel MVS has been a huge help for our lab in validating volumes on new automated liquid handlers. Always gives consistent results, easy to use, software is extremely straightforward, and any time we have an issue, it's super easy to get help from the Artel team. Thank you!

Leah Chong


The MVS system is extremely useful for periodic performance QC testing of high-throughput liquid handlers, high-throughput liquid handler calibration, and various liquid handler/single channel pipette tip type/lot QC. The MVS system requires minimal maintenance and MVS manager software is intuitive to use and flexible to set up various plate layouts to meet user’s need. The customer service is very responsive and helpful. They provide a notification for calibrator plate re-certification annually ...

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The [Artel MVS] product is accurate and reliable. With the addition of the pre-owned models of MVS readers, it also becomes affordable. The expansion of the dye solutions to include MasterMix and Serum along with their original aqueous offering makes Artel a definitive liquid class setup solution. The FSE performing setup and the account manager were on-time, responsive, and supportive during install and (most importantly) afterwards.

Kevin Kim

Avellino Labs

The small footprint of this instrument is great for our lab! The Anoxomat is a workhorse and has given us very few problems historically. Ease of use among many users and quality, reproducible results are a given with this instrument.

Jessica Gabriel

Northside Hospital Gwinnett

The Osmo1 is a wonderful instrument. You can rely on the results. When testing in duplicate the results are always within 2 of the original results. The analyzer is simple to use and maintain. I have used an analyzer like this for 15+ years and have never had an instrument related failure. Advanced Instruments offers the supplies that a medical laboratory scientist needs to perform linearities, quality controls, and set standards for this analyzer. ...

Regenia Zeringue

Sky Lakes Medical Center

Advanced Instruments Osmo 1 Single [sample osmometer] is an exceptional product. It is user friendly and easy to train new employees and students. The user guide is extremely detailed and thorough and easy to follow along. The instrument is reliable and using only faults due to human error. Great product!

Lacey Campbell

Springhill Medical Center

We love our Osmo1 single [sample osmometer]. It's simple to calibrate, clean, and maintain. The precision and accuracy is much better [than] our previous Fiske 210 model and the Protinol and Renol controls are very stable.

Lacey Campbell

Springhill Medical Center

The Artel pipette calibration system has completely streamlined our calibration program. The amount of downtime due to uncalibrated pipettes and pipettes requiring external calibration has been reduced. Non-conformance due to calibration has been eliminated.

Bryan Waters

MPI-Animal Health Laboratory

[With the Artel PCS], we run pipette calibrations for multiple sections and push through 200+ pipettes in 2 months…We love the access to the computer to make saving and printing the results so much easier especially where we have to file away information for 7 separate labs each with their own set of pipettes.

Ashley Aurand-Cravens

KY Divisions of Lab Services

We use an Artel PCS system to calibrate our pipettes. We purchase all the reagents necessary to use. Have contacted Artel Technical support for questions in regard to using the Artel system and necessary trouble shooting suggestions. Happy with the service for purchase of the system that we are using and the products. Verification of pipettes using this system has saved us time and provided more accurate results compared to using balances for verification of pipettes in particular small volumes.

Fathieh Shafiee

Wisonsin Department of Agriculture, Trade and Consumer Protection

Artel PCS is very easy to use. The results are consistent between different users. The software is user friendly and makes it easy to keep schedules and calibration plans organized. It has sped up the calibration process.

Vicki Duch

St.Jude Children's Research Hospital

The MVS system is fairly intuitive to use. Not only can we use this for our internal automated liquid handler volume verification, tip test and calibration work, we have been using the system to offer external volume verification service to our collaborators. The system is very durable without significant issues and easy to maintain. MVS reagent orders are always processed and delivered in a timely manner. Our regional specialist periodically checks in to ask if the system is working as expected.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The Anoxomat has been extremely useful in the growth and care of anaerobic cultures in my laboratory and allows us for advanced patient care when it comes to cultures that grow a variety of microbiological organisms. At the push of a button, we are able to simulate anaerobic conditions ideal for their growth.

Scott Connolly

VA Boston Healthcare

The Anoxomat system is easy to use, has very little maintenance and consistently gives good growth of quality control organisms.

Janet Reynolds

Grandview Medical Center

Ease of use and reproducibility of results are excellent. I would recommend [Anoxomat] for any microbiology department to ensure proper anaerobic conditions are met!

Stefanie Taitano

Keesler Air Force Base

We have no problems recovering fastidious anaerobes and microaerophilic organisms such as Campylobacter. The [Anoxomat] instrument is easy to use with very few problems. Our techs like the disposable sachets ... there is one less task for the techs to monitor and perform.

Terry O'Donnell

Mount Carmel Health System

Anoxomat is the best anaerobic system. In our lab settings, anaerobic bacteria's isolated from deep tissue and fluid samples using this system with flexibility while maintaining quality. Besides anaerobic environment, it can also provide microaerophilic, or custom environments, such as capnophilic, depending on requirements. It also offers users the ability to program recipes with the optional “User-Generated Recipes” function.

Asma Siddiqua


The Osmo1 osmometer is a very simple to use osmometer. The instrument is reliable, robust, accurate and very fast at collecting data. Our department have been using it for over a year and a half and I have never experienced any big issue with it. ... Overall, it is a high-quality instrument, accurate results, easy to use.

Haileab Ghebrekidan


The Osmo1 follows in the footsteps of its predecessors like the 3250. The introduction of barcode scanning and touch screen has provided better functionality and connectivity. The device has rock solid performance and uses the same supplies as the 3250. Advanced Instruments is definitely the market leader when it comes to osmolality measurement with accurate results for patient clinical use in a 24/7 environment.

Ken Onuska

Halton Healthcare

I am the technical specialist for the area. The ease of use and small sample volume needed are what has impressed me the most [about the Osmo1]. Also, the programming ability. The team we deal with here in the Halifax area are exceptional and are always here to help in any way necessary. The instruments allow us to produce not only a quality result, but we do it the most efficient way possible.

Erica Mayo


Great customer service, the FSE was knowledgeable and personable. The analyzer, which was an updated version of our previous osmometer, provides ease of use, updated technology, and produces accurate and reproducible results. The Osmo1 single sample micro osmometer makes maintaining regulatory compliance simple.

James DeGori

HNL Lab Medicine

The Osmo1 was very easy to set up. Instructions were easy to follow. I like that the printer is incorporated into the analyzer and that the consumable boxes have sensors that count down the number of tips left. Very easy for staff to use.

Karen Thompson

SSM Health DePaul Hospital - St.Louis

The [OsmoPRO] is a nice instrument! AI provides excellent customer service. This is the second osmometer I've purchased from them, and the second was largely due to the excellent phone technical support. ...

Lisa Herickhoff


The [OsmoPRO's] auto-sampling allows walkaway operation for multiple patient samples; we also have a lot fewer issues with pre-freeze errors from improper cleaning of the chamber.

Nathan Okawa

Ronald Regan UCLA Medical Center

The [OsmoPRO] osmometer is technically easy to use and decreases total sample run time and user commitment time. It is a reliable instrument. The thing I really appreciate about Advanced Instruments is their awesome phone technical support! ... Overall, I would buy again. And I would definitely purchase from Advanced Instruments.

Lisa Herickhoff


The [OsmoPRO] has helped with testing and being able to batch tests and walk away from the instrument. The staff were very happy when we received this instrument. Easy to use. Maintenance is simple. Results are reliable and consistent. No duplicate or triplicate testing anymore. Very little downtime. Had to change the probe once but took minutes.

Judy Przybyla

Oishei Children's Hospital

The Anoxomat III is an efficient instrument. It continues to provide anaerobic conditions for our anaerobic chambers with consistent results. It is relatively easy to use. You can add additional plates to a jar after it has been charged, just remember to let the jar come to atmospheric conditions for a minute before you recharge it. ...

Patrick McGeehan

Capital Region Medical Center

The Protinol and Renol QC that Advanced Instruments offers is just what our lab needed to verify and feel confident in our instrument's performance at clinically relevant levels. Our original QC material was only assessing abnormal high values. Now ... we have QC that measures low, normal and high values, which helps us stay in control at all decision points. ... no more thawing so saves time! ... Now we can easily scan the provided barcodes ... to ensure all results make it to the LIS. It has helped us stay more organized and eliminated manual entry of results. ...

Lab Personnel

West Coast Medical Center

We were doing liquid class development and realized that we couldn’t get anything <10 uL to pass. With the MVS, I was able to optimize our liquid classes in just 6 tests! We took it from a 16% inaccuracy down to 1.6% at 10 uL. Piece of cake when you’ve got something like the MVS in your corner.

Douglas Brown

CRL Clinical Reference Laboratory

The MVS system has been vital to our lab operations.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

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