Clinical Chemistry | Advanced Instruments
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Clinical Chemistry

Osmolality measurement is a low-cost, high-value clinical tool in the diagnosis of and patient management for a variety of conditions.

Osmolality testing enables hospitals to increase quality of patient care while reducing costs

Osmolality is a quick and effective test to help:

  • Evaluate the body’s water balance and its ability to produce and concentrate urine
  • Investigate low sodium levels (hyponatremia)
  • Detect the presence of toxins in the body
  • Monitor the electrolyte balance of patients receiving osmotically active drug therapies (e.g. mannitol used to treat cerebral edema)

Importance of Measured Osmolality

Direct measurement of body fluid osmolality with a freezing point depression osmometer is the preferred method when reporting osmolality in a clinical setting1.

In practice, physicians use both measured and calculated osmolality to determine a patient’s osmolal gap. The difference between measured and calculated osmolality can be diagnostically significant for conditions such as toxic alcohol ingestion, and useful for monitoring patients being treated with osmotically active therapies.

If a laboratory were to solely provide calculated osmolality physicians could not calculate the osmolal gap to screen for foreign substances.

The Value of STAT Osmolality Testing

Advanced Instruments products use the gold-standard freezing point depression method to ensure accurate results for confident reporting. We offer a variety of clinical osmometers to meet your sample throughput and automation needs and ensure you are ready for the quick turnaround needed for high-value STAT testing. Better for the patient; better for you.

The Value of Our Clinical Osmometers

Our portfolio of osmometers deliver the ease-of-use features demanded by labs to ensure they stay productive. Easily integrated into any lab workflow, our instruments offer the level of automation needed to ensure maximum productivity, so labs can handle any level of sample testing in an efficient manner. With increasing levels of staff shortages and continued challenges this is of utmost importance.

User-Friendly Features

  • Small sample volumes improve test flexibility
  • Flexible user settings increase patient data security and integrity
  • On-board printer and network connectivity enable simpler reporting
  • Automated cleaning on multi-sample instruments reduces hands-on time
  • Primary tube loading on the OsmoPRO MAX allows full walk-away testing

Gold Standard Technology
Our osmometers rely on our gold-standard freezing-point depression technology to provide the patient results you’ve trusted for decades.

  • Freezing point depression osmolality measurement
  • 2- or 3-point calibration
  • On-board Levey-Jennings charts

Osmo1 is very easy to use, reproducibility is great. Customer service is friendly and easy to use.

Christina Quondam Franks, Saint John Regional Hospital

Popular Educational Resources

Learn more about the basic principles of osmolality testing as well as the benefits of our osmometers.

Application Note

Clinical Osmometer Applications

Advanced Instruments Osmometers can improve your workflow and increase efficiency in a wide variety of fields.

Advanced Instruments Osmometers can be used in multiple situations to improve patient outcomes.


The Value of Osmolality Testing

Hospitals and health systems can include measured osmolality in clinical pathways for these conditions to help reduce cost of care and improve quality of care.

Scientific Literature

The Importance of Measuring Osmolality in Monitoring and Managing COVID-19 Patients

Osmolality testing can be used to diagnose hyponatremia, and electrolyte disorder that is occurring in some COVID-19 patients.

Associated Products

OsmoPRO® MAX Automated Osmometer

Built for clinical laboratories of all sizes, the OsmoPRO MAX delivers unprecedented automation, ease of use, and efficiency. Innovative flow-through technology revolutionizes osmolality testing by eliminating manual pipetting and consumables.

Osmo1® Single-Sample Micro-Osmometer

With the Osmo1 Single-Sample Micro-Osmometer, we’ve bundled together accurate and reliable osmolality measurement with ease-of-use for efficient patient sample analysis. Easily maintain regulatory compliance while ensuring the security and integrity of patient data with the Osmo1

OsmoPRO® Multi-Sample Micro-Osmometer

Automated testing and cleaning saves labor time, freeing up staff for other tasks in the lab.

A convenient carousel design that handles up to 20 samples includes an intuitive touchscreen interface, and delivers industry-leading performance

Protinol™ and Renol™Osmolality Controls

Manufacturer-recommended QC helps labs comply with CAP and CLIA guidelines


Clinical Services

Get the best performance from your instrument from the people who designed and built it. We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your osmometers, anaerobic jar systems, CSF cell counters, and neonatal bilirubin stat analyzers.