Clinical Industry

Patient Osmolality Testing

Manage higher workloads while maintaining a high quality of service with clinical technology that streamlines diagnosis and patient management.

Increase the Quality of Patient Care While Reducing Costs

Osmolality is a quick and effective test to help:

  • Evaluate the body’s water balance and its ability to produce and concentrate urine.
  • Investigate low sodium levels (hyponatremia).
  • Detect the presence of toxins in the body.
  • Monitor the electrolyte balance of patients receiving osmotically active drug therapies (e.g. mannitol used to treat cerebral edema).

Importance of Measured Osmolality

Direct measurement of body fluid osmolality with a freezing point depression osmometer is the preferred method when reporting osmolality in a clinical setting.

In practice, physicians use both measured and calculated osmolality to determine a patient’s osmolal gap. The difference between these can be diagnostically significant for conditions such as toxic alcohol ingestion, and useful for monitoring patients being treated with osmotically active therapies.

If a laboratory were to solely provide calculated osmolality physicians could not calculate the osmolal gap to screen for foreign substances.


The Value of STAT Osmolality Testing

Our products use the gold-standard freezing point depression method to ensure accurate results for confident reporting. We offer a variety of clinical osmometers to meet your sample throughput and automation needs and ensure you are ready for the quick turnaround needed for high-value STAT testing. Better for the patient; better for you.


Access our Popular Educational Resources

Learn more about the basic principles of osmolality testing as well as the benefits of our osmometers - check out our comprehensive educational resources

Clinical Case Study

Improving cell count turnaround times with the GloCyte Automated Cell Counter for CSF


Clinical App Note

Clinical Osmometers: Meeting the Increasing Need for Workflow Efficiency


Clinical App Note

Clinical Osmometer Applications


Clinical App Note

Osmolality: A Crucial Medical Tool for a Vast Range of Use Cases


Clinical Webinar

Virtual Clinical Osmometer Demo


Clinical Webinar

Speed up Assay Development Time when Testing Plasma and Other Viscous Liquids


Clinical Webinar

Serum Osmolality Disorders — Importance, Evaluation and Treatment


Clinical Posters

Improving cell count turnaround times with the GloCyte® Automated Cell Counter for CSF


Clinical Posters

Shining Renewed Light on a Tried-and-True Test: The Critical Role of Osmolality Testing in Improving Health and Economic Outcomes in Patients with Hyponatremia


Clinical Posters

A Shift From Manual to Automatic: CSF Cell Counts With the GloCyte® Automated Cell Counter System


Clinical Knowledge Center

Pipetting Viscous Solutions


Clinical Knowledge Center

Importance of Measured Osmolality


Clinical Knowledge Center

Pipetting Technique Training – Transferability of Pipette Calibrations and Proficiency of Operators


Associated Products

Clinical Services

Get the best performance from your instruments from the experts who designed them. We provide a range of services and service plans to meet your specific needs.

Our certified Field Service Engineers provide on-site, professional installation, training, validation, and system maintenance support of your osmometers, anaerobic jar systems, CSF cell counters, liquid handling performance verification technology and neonatal bilirubin stat analyzers.

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I have set up and trained fellow employees on how to use the PCS Pipette Calibration system over all of our laboratory departments and three hospitals. It is easy to use and understand how to use it in step-by-step instructions while calibrating and setting up pipettes for calibrations.

Angela Achneider

Consultants Laboratory, Agnesian Healthcare

The PCS Pipette Calibrations system is easy to use. The Artel Calibration Standard set is customizable to your set of pipettes. Their service team works hard to match the kit to individual site needs. Capable of calibrating single and multichannel pipettes.

Kathryn Traughber

Tri Cities Laboratory

[Protinol and Renol produce] great results with the analyzer we use. Excellent quality and easy to use.

Audra Wilson

Meadows Regional Medical Center

The [Osmo1] is a valuable tool within our facility. The set up was extremely easy. There are a lot of features for programming if you require passwords for individual users or if you just want any lab personnel to be able to run a sample. ... . Maintenance is easy to perform, it is not time consuming, or something you need to dig out the manual for complex instructions. The supply pack has a sensor in it so when consumables need to be replaced it will auto-update the supplies and alert when supplies are >50...

Judy McCormick

Meno Ya Win Hospital

The Osmo1 is a wonderful instrument. You can rely on the results. When testing in duplicate the results are always within 2 of the original results. The analyzer is simple to use and maintain. I have used an analyzer like this for 15+ years and have never had an instrument related failure. Advanced Instruments offers the supplies that a medical laboratory scientist needs to perform linearities, quality controls, and set standards for this analyzer. ...

Regenia Zeringue

Sky Lakes Medical Center

Advanced Instruments Osmo 1 Single [sample osmometer] is an exceptional product. It is user friendly and easy to train new employees and students. The user guide is extremely detailed and thorough and easy to follow along. The instrument is reliable and using only faults due to human error. Great product!

Lacey Campbell

Springhill Medical Center

We love our Osmo1 single [sample osmometer]. It's simple to calibrate, clean, and maintain. The precision and accuracy is much better [than] our previous Fiske 210 model and the Protinol and Renol controls are very stable.

Lacey Campbell

Springhill Medical Center

The Artel pipette calibration system has completely streamlined our calibration program. The amount of downtime due to uncalibrated pipettes and pipettes requiring external calibration has been reduced. Non-conformance due to calibration has been eliminated.

Bryan Waters

MPI-Animal Health Laboratory

[With the Artel PCS], we run pipette calibrations for multiple sections and push through 200+ pipettes in 2 months…We love the access to the computer to make saving and printing the results so much easier especially where we have to file away information for 7 separate labs each with their own set of pipettes.

Ashley Aurand-Cravens

KY Divisions of Lab Services

We use an Artel PCS system to calibrate our pipettes. We purchase all the reagents necessary to use. Have contacted Artel Technical support for questions in regard to using the Artel system and necessary trouble shooting suggestions. Happy with the service for purchase of the system that we are using and the products. Verification of pipettes using this system has saved us time and provided more accurate results compared to using balances for verification of pipettes in particular small volumes.

Fathieh Shafiee

Wisonsin Department of Agriculture, Trade and Consumer Protection

Artel PCS is very easy to use. The results are consistent between different users. The software is user friendly and makes it easy to keep schedules and calibration plans organized. It has sped up the calibration process.

Vicki Duch

St.Jude Children's Research Hospital

The Osmo1 osmometer is a very simple to use osmometer. The instrument is reliable, robust, accurate and very fast at collecting data. Our department have been using it for over a year and a half and I have never experienced any big issue with it. ... Overall, it is a high-quality instrument, accurate results, easy to use.

Haileab Ghebrekidan


The Osmo1 follows in the footsteps of its predecessors like the 3250. The introduction of barcode scanning and touch screen has provided better functionality and connectivity. The device has rock solid performance and uses the same supplies as the 3250. Advanced Instruments is definitely the market leader when it comes to osmolality measurement with accurate results for patient clinical use in a 24/7 environment.

Ken Onuska

Halton Healthcare

I am the technical specialist for the area. The ease of use and small sample volume needed are what has impressed me the most [about the Osmo1]. Also, the programming ability. The team we deal with here in the Halifax area are exceptional and are always here to help in any way necessary. The instruments allow us to produce not only a quality result, but we do it the most efficient way possible.

Erica Mayo


Great customer service, the FSE was knowledgeable and personable. The analyzer, which was an updated version of our previous osmometer, provides ease of use, updated technology, and produces accurate and reproducible results. The Osmo1 single sample micro osmometer makes maintaining regulatory compliance simple.

James DeGori

HNL Lab Medicine

The Osmo1 was very easy to set up. Instructions were easy to follow. I like that the printer is incorporated into the analyzer and that the consumable boxes have sensors that count down the number of tips left. Very easy for staff to use.

Karen Thompson

SSM Health DePaul Hospital - St.Louis

The [OsmoPRO] is a nice instrument! AI provides excellent customer service. This is the second osmometer I've purchased from them, and the second was largely due to the excellent phone technical support. ...

Lisa Herickhoff


The [OsmoPRO's] auto-sampling allows walkaway operation for multiple patient samples; we also have a lot fewer issues with pre-freeze errors from improper cleaning of the chamber.

Nathan Okawa

Ronald Regan UCLA Medical Center

The [OsmoPRO] osmometer is technically easy to use and decreases total sample run time and user commitment time. It is a reliable instrument. The thing I really appreciate about Advanced Instruments is their awesome phone technical support! ... Overall, I would buy again. And I would definitely purchase from Advanced Instruments.

Lisa Herickhoff


The [OsmoPRO] has helped with testing and being able to batch tests and walk away from the instrument. The staff were very happy when we received this instrument. Easy to use. Maintenance is simple. Results are reliable and consistent. No duplicate or triplicate testing anymore. Very little downtime. Had to change the probe once but took minutes.

Judy Przybyla

Oishei Children's Hospital

The Protinol and Renol QC that Advanced Instruments offers is just what our lab needed to verify and feel confident in our instrument's performance at clinically relevant levels. Our original QC material was only assessing abnormal high values. Now ... we have QC that measures low, normal and high values, which helps us stay in control at all decision points. ... no more thawing so saves time! ... Now we can easily scan the provided barcodes ... to ensure all results make it to the LIS. It has helped us stay more organized and eliminated manual entry of results. ...

Lab Personnel

West Coast Medical Center

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