Solentim VIPS® PRO Single Cell Seeder

High efficiency single cell seeding with image based proof of clonality for GMP-compatible workflows

[With the VIPS PRO], we can trace back the data to the single cell, select from our top 48 cell lines, and report all the information – our proof of monoclonality is already in there, and that’s really nice.

Jolanda Gerritsen / Genmab

Elevating single cell seeding workflows: Delivering proof not probability in monoclonality

Optimize your workflow productivity and get complete confidence in single cell seeding and clonality assurance. VIPS PRO® delivers proprietary artificial intelligence-driven cell recognition for accurate detection of your high-value cells and helps to de-risk your regulatory submission with definitive, imaged-based proof of monoclonality. Labs get high seeding efficiency, certainty of clonality, superior imaging with advanced data management, and GMP-certified features.

Highlighted features
  • High-efficiency single cell seeding 
  • Intelligent cell recognition 
  • Single-use seeding kits 
  • Proof of monoclonality
  • STUDIUS™ compatibility

High value cell workflows relying on CHO, HEK and iPSC-derived cells, all start with VIPS PRO

Designed for processes utilizing Master Cell Banks, VIPS PRO combines high performance seeding with the capture of quality evidence of clonality at two different time points providing the best possible start to your process. During the clonal growth phase, VIPS PRO performs daily high-clarity whole well imaging, recording a timeline of well images and performing analysis to measure confluency.

Benefits

Proof of monoclonality, not probability

With VIPS PRO, clonal assurance is based on evidence of a single cell- not statistical probability. VIPS PRO delivers evidence at multiple steps for complete certainty of single cell seeding.

Droplet image of a single cell on day 0

Images of the single cell in the bottom of the dry well are collected as evidence of seeding, after which the sophisticated neural network identifies individual cells, cell aggregates, and other non-cell artifacts.

Single cell whole-well imaging

The timeline of clonal outgrowth continues with high-clarity, whole-well imaging starting at day 0, tracing back to a single cell to confirm monoclonality for confident regulatory submissions. Supported plate types: 384, 96, 48 and 12 well plates.

Take single cell cloning to a new level of quality and confidence

  • Cell Reservoir (CR) comes preassembled and ready-to-use
  • Ceramic nozzle delivers optimal droplet formation and seeding efficiency
  • Transparent reservoir enables visual inspection of the cell suspension
  • Low starting material requirements preserves precious cells
  • Suitable for use with CHO, HEK293, and sensitive cell types such as iPSCs

  • Submission-ready, high-quality, image-based proof of clonality
  • Droplet and whole-well images captured on day 0 through outgrowth
  • Know on day 0 if the cell suspension was prepared to the correct dilution
  • Automated dynamic clonality report streamlines regulatory submission

  • Artificial Intelligence-driven (AI) algorithm enables automated
    accurate cell detection
  • Neural network can detect single cells within droplets
  • Differentiates between single cell, cell aggregates, debris, and air bubbles

  • Integrated STUDIUS™ software platform for instrument control
    and powerful data analysis and management
  • Enables data sharing within the Solentim Ecosystem
  • Sample tracking with complete audit trail

  • Gamma-irradiated, single-use Seeding Kits
  • Eliminate sample carryover and contamination between projects
  • Compatible with GMP workflows

  • VIPS PRO is the only single cell seeder that is certified for GMP manufacturing
  • Single-use Seeding Kits
  • Security features support 21 CFR Part 11 compliance and data integrity
  • System access control for authorized users
  • Database backup and audit trail for record-keeping

  • Tubing, cell reservoir, and VIPS PRO accessory tray positioned at
    the front of the instrument for better access and ease-of-use
  • Optimized design improves airflow in the laminar flow hood to keep contaminants away from cells

  • AI-driven algorithm for extremely precise confluence readout
  • Assess clonal outgrowth of various cell morphologies including iPSCs and MSCs
  • Easy clone selection based on clonality and growth rates.

Solentim Ecosystem: Bringing total consistency across cell line development

STUDIUS incorporates critical data from VIPS® PRO single cell seeding, Cell Metric® X clone verification and colony outgrowth monitoring, and ICON™ cell IgG productivity assessments, allowing scientists to make faster and more confident decisions. STUDIUS analyzes data automatically and instantly, according to user-defined parameters, delivering ranking and selection of clones, within minutes—a process that previously took hours or days.

SpecDescription
Dimensions (D x W x H) 19.68 x 18.74 x 15.43" (39.2 x 47.6 x 50 cm)
Net Weight83.77 lbs (38 kg)
Operating ConditionsIndoor use only
Temperature: +10 °C (50 °F) to 40 °C (104 °F)
Humidity: 20% to 80% non-condensing
Altitude: Up to 2000M
Mains Supply: +/- 10% rated voltage
Electrical SupplyPower Supply Input Voltage: 100-240V AV 50-60Hz Single Phase
Power Supply Output Voltage: 24V DC – 250W
Power Supply Input Connection: IEC Input

VIPS PRO Single-use Seeding Kits

The main consumables for our single-cell seeder and imager- VIPS PRO. Pre-assembled and ready-to-use kits come with all the parts required to set up a seeding process and seed multiple plates from only 3mL of cell suspension.

CC-5116 VIPS PRO Single-use Seeding Kit (standard)
CC-5117 VIPS PRO Single-use Seeding Kit (GMP)

Additional Spare Parts

CC-2122VIPS Cell Reservoir Nozzles (5 pack)1
CC-2123 VIPS Cell Reservoir Nozzles (10 pack)1
CC-2019VIPS Purge Tracy (1 pack)
  1. compatible with non-GMP kits (CC-5116)

Other Consumables

Recommended Media Bottles
Provider Part Number Description
Thermo Fisher 455-0250 Nalgene™ Rapid-Flow™ Sterile Filter Storage Bottles, 250 ml (pack of 24)
Fisher Scientific 15913317 Fisherbrand™ Polystyrene Storage Bottles, 250 ml (pack of 24)

Other Consumables

Compatible Plate Types
Plate Format Application
96-well plates Single-cell seeding & whole well imaging
384-well plates Single-cell seeding & whole well imaging
12-well plates Whole well imaging*
48-well plates Whole well imaging*
*- chosen scan types only

For a comprehensive list of validated plate types, please refer to MAN-125 STUDIUS Microplate Matrix.

 

Nalgene™ and Rapid-Flow™ are Trademarks of Thermo Fisher, Fisherbrand™ is a trademark of Fisher Scientific.

VIPS PRO is the perfect choice for:

  • Cell line development (CLD) for biologics
  • Gene therapy for viral vector production
  • Cell Therapy for use with human and induced pluripotent stem cells
Solentim Cell Metric® X
Clonal imager with automated assurance

Simplify clonal assurance with Artificial Intelligence

Learn more
Solentim ICON™
Clone & Protein Biologic Analyzer

Analyze VCD, titer and productivity for selection of the highest value clones.

Learn more
STUDIUS™
Data management software platform

Data management for the highest level of consistency across the CLD workflow

Learn more
Solentim iPSC Matrices

High Viability iPSC Single Cell Cloning and Outgrowth

Learn more
Cell Growth Reagents

Cell growth supplements which improve cell growth and accelerate cell line development workflows for CHO and HEK cells.

Learn more

Services

Protect your investment with an Advanced Care service agreement from Advanced Instruments. Take the worry out of service costs and have total peace of mind knowing that your instrument is covered.

Learn more
Poster

Optimizing the process development protocols for promoting highest viability growth of iPSCs during single-cell cloning

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Application Note

Clonality in Stem Cell Derived Therapies, a Journey From Process Development to Manufacturing

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Case Study

Single cell cloning of FACS-sensitive cells using the VIPS

Download Now

Want to see what the VIPS® PRO can do for your workflow?

BOOK A VIRTUAL DEMO

What our customers say

[With the VIPS PRO], we can trace back the data to the single cell, select from our top 48 cell lines, and report all the information – our proof of monoclonality is already in there, and that’s really nice.

Jolanda Gerritsen

Genmab

The Enhanced Clonality Reports easily generated by the VIPS/Cell Metric software allows us to track both cells and potential debris from first inception of the single cell in the well, to full-grown colonies enabling us to provide our customers with full traceability and audit trail of each cell line we produce for them with a single, well-crafted document.

Camile Evenou

Celonic AG

The VIPS™ is unique, being the only single cell cloning system on the market that tracks a single cell’s arrival in the actual well with high resolution (z-stack) imaging and to support the subsequent daily whole well imaging provided by the Cell Metric.

Camile Evenou

Celonic AG

The VIPS system allowed us to shave off a few months from our development timeline and select highly stable single clones for manufacturing purposes.

Andy Tsun

Discovery Biology, Biotheus Inc.

The VIPS™ system and software has helped our company to deliver a high-quality data-package that meets global regulatory standards...The ease of use and reliability of the VIPS freed up valuable time.

Andy Tsun

Discovery Biology, Biotheus Inc.

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For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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Request a Virtual Demo

For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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