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Solentim ICON™ Productivity Analyzer

Combined human IgG1 titer, VCD and productivity analyzer
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Streamlining ranking and selection of productive clones

The ICON enables scientists in the biotherapeutic development industry to digitally transform their process and make informed decisions quicker, earlier, and more securely. ICON measures titer, viable cell density, and specific productivity in the Cell Line Development of therapeutic antibodies. It is integrated into the STUDIUS™ decision making platform which combines ICON productivity data with clonality and confluence data from Cell Metric® X and/or VIPS® PRO to rank clones automatically, instantaneously, and without error.

Highlighted features
  • Combined Cell Viability and Titer assays
  • Low volume assays
  • Rapid titer assay
  • STUDIUS data management compatible

Cell viability and productivity assays in one instrument

Rapid Productivity assays

The ICON titer assay is relatively fast and involves fewer preparation steps compared to the incumbent assays.

Efficient use of bench-space

Prior to ICON, two instruments were required to measure cell viability and productivity, with an associated price tag. ICON is an efficient use of space due to combining both measurements in one box at a price considerably lower than that associated with two separate units.

Industry Applications

Low volume productivity assay

Titer is measured using fluorescence polarization and needs only 60 μl per assay. This means that titer can be measured earlier in the process, for example in Day 14 static cloning plates or 48 or 24 DW suspension shaking plates. Earlier titer measurements allow earlier stratification of high producing clones.

Low volume cell viability assay

Viable cell density is measured using Trypan blue exclusion. Cultures up to 10 million cells/mL can be counted and the count is qualified with a supporting high resolution image showing the denotation of live versus dead cells. The assay requires only 20 μL of sample, much less than incumbent cell viability analyzers requiring several hundreds of microliters.

Product Features

  • Automatic ranking of titer and viable cell density
  • Eliminates human intervention and errors
  • Performed immediately and according to defined parameters

  • STUDIUS compliant
  • Sample tracking throughout CLD process from seeding to selection

  • Titer measure needing only 60 μL per assay
  • Viable cell density measure needing only 20 μL per assay
  • Earlier titer measurements allowing for earlier stratification of high producing clones

  • Titer measured using fluorescence polarization
  • Viable cell density measured using Trypan blue exclusion

  • Show denotation of live versus dead cells
  • Intuitive STUDIUS user interface

  • 96 samples for titer in 6 minutes
  • 24 cell viability samples in under 4 minutes

FAQs

The titer plates are coated with Protein G which binds to the Fc portion of IgG molecules.

The ICON can complete 24 cell counts in under 4 minutes.

Combining viability and titer in one instrument saves bench-space and cost, Low volume assays allow scientists to make clone selection decisions earlier, Faster and more accurate titer measurements

By providing consistency across the entire cell line development workflow from seeding to clone selection

  • Elimination of human error in the analysis and interpretation of clonality, titer and viability results
  • Tracking of clones across the cell line development process from seeding to selection
  • Reduction of analysis time related to clone selection from days to minutes
Spec Description
Dimensions (D x W x H) 48.5 x 46.5 x 32.5 cm
Net Weight 35 kg
Operating Conditions Indoor use only
Temperature: +10 °C to 40 °C
Humidity: 20% to 80% non-condensing
Altitude: Up to 2000M
Mains Supply: +/- 10% rated voltage
Electrical Supply Power Supply Input Voltage: 100-240V AV 50-60Hz Single Phase
Power Supply Output Voltage: 24V DC – 250W
Power Supply Input Connection: IEC Input

ICON Titer Plates

Compatible with ICON, ready to use, 96-well assay plates for IgG quantification.

  • RS-3221 ICON Titer Assay Plate – Plate based IgG assay for cloning plates. Five plates, each for 96 well samples. For 2.5 mg/L – 100 mg/L.
  • RS-3223 ICON Titer PLUS Assay Plate – Plate based IgG assay. Five plates each for 96 well samples. For 100 mg/L – 1500 mg/L.

ICON Cell Counting Slides

ICON offers automated cell counting and viability measurements for cells in suspension, enabling between 1 and 24 counts in a single run.

  • RS-3010 ICON Cell Counting Slides (8 counts per slides x 15 slides in box); 15 x Cell Counting slide for 8 counts each using 20 μl cell suspension.

STUDIUS™

The smartest decision-making platform in cell line development.

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InstiSHAKE™

InstiSHAKE CHO and InstiSHAKE HEK as a follow on supplement in the transition to deep well plates.

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ICON is the perfect choice for:

  • Cell line development for biologics
Solentim Cell Metric® X
Clonal imager with automated assurance

Simplify clonal assurance with Artificial Intelligence

Learn more
Solentim VIPS® PRO
High efficiency, single cell seeding and imaging platform

High efficiency, single cell seeding with image-based proof of clonality for GMP-compatible workflows

Learn more
STUDIUSTM
Data management software platform

Data management for the highest level of consistency across the CLD workflow

Learn more

Services

Protect your investment with an Advanced Care service agreement from Advanced Instruments. Take the worry out of service costs and have total peace of mind knowing that your instrument is covered.

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Webinar

Employing Tools Of ICON To Advance Selection Of The Highest Producing Clones

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Scientific Poster

Improving Cell Line Development Processes Through Accurate, Low Volume and Rapid Automated Cell Counting and Viability on the ICON™ Instrument Using STUDIUS™ Data Management Software

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Applicaton Note

How STUDIUS™ Is Changing Cell Line Development

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Want to see what the ICON can do for your workflow?

BOOK A VIRTUAL DEMO

Request pricing

For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

Download Brochure

Please fill out this brief form to download this content. You can also get in touch with our sales team for product questions, arranging a product demonstration or obtaining a quotation at the phone numbers below:

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

Request a Virtual Demo

For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366