Solentim ICON™ Protein Biologic Analyzer

All-in-one clone and protein biologics characterization

The Solentim ecosystem, [VIPS , Cell Metric, ICON], allowed Wheeler to rapidly develop and launch a standardized cell line development service that is integrated with a scalable drug substance process.

Mike Brem / Wheeler Bio

Revolutionize your clone selection process with ICON

The ICON uses low-volume, high-throughput assays to measure titer and CQAs, which in combination with the integrated STUDIUS decision making platform, combines data to produce accurate clone triaging parameters to identify the best performing clones automatically, instantaneously, and without error.

Highlighted features
  • VCD, titer and CQA assays dedicated to CLD
  • Low sample volumes
  • High throughput
  • Liquid handler compatible

Clone and Protein Biologics Characterization All In One Instrument

  • Top-down fluorescent polarization reader for the rapid assessment of IgG and Fc-containing protein concentrations in crude supernatant using the ICON Titer Assay Plates

  • Building on the legacy of the Cell Metric®, the ICON has unparalleled
    whole well imaging capabilities for proof of monoclonality and colony outgrowth screening.

  • Bottom-up fluorescent imager for the rapid assessment of critical quality attributes (CQA) of IgG and Fc-containing protein concentrations in proprietary assay plates.

  • A bench-top instrument meaning all analysis can be performed in the CLD lab, removing the need for sample transfer to analytical departments.

Product Features

  • Generate submission-ready, high-quality, image-based proof of clonality with multi-plane whole-well imaging on day 0.

  • The proprietary artificial intelligence (AI)-driven colony detection and confluence quantitation allows for seamless tracking of clonal outgrowth for titer normalization to exclude poor performing clones as early as the 384-well plate stage.

  • All ICON assays require low sample volumes and minimal sample preparation, for a high-throughput sample-to-data workflow from the 384-well plate stage, all the way through to protein biologic characterization in the bioreactor.

  • Clones can be effortlessly tracked from single cell to bioreactor,
    and triaged at every stage for clonality, outgrowth, titer and CQA.

  • The ICON and all associated features can be seamlessly integrated with the VIPS® PRO and Cell Metric X HT for single cell seeding and high-throughput clonal imaging, respectively, to be flexible to your lab’s demands.

  • Whether it’s transferring clones from the 96-well source plate, or preparing a batch of Titer Assay Plates, all ICON applications are fully compatible with liquid handling platforms.

Now partnered with PAIA Biotech for a cutting edge combination facilitating the semi-quantitative screening of critical glycan features and ranking samples in the CLD laboratory within hours

Low Sample Volumes – Screen for Glycans at Every Stage of CLD

• Only 10 μL per replicate, per glycan
• Glycans can be screened alongside the ICON Titer Assay
• Screen glycan profiles as early as the 96-well plate

Multi-biologic Compatibility – Flexible to Meet Every Project’s Requirements

• Fluorescent-labeled lectins will bind to a variety of protein biologics
• IgG from multiple species and Fc containing proteins
• ICON and associated assays are flexible to your projects demands

Minimal Sample & Assay Handling – Automation Friendly Assays for Unparalleled Throughput

• Cell culture supernatant screening possible
• No arduous washing steps
• Readily incorporated into automated liquid handling workflows

Multi Glycan Screening – Increasing your Power to Produce High-Quality Biologics

• Up to six glycans can be measured simultaneously
• High mannose, (terminal) galactose and fucose on N-glycans, and sialic acids on N- and O-glycans
• Increasing the power of the end-user for producing biosimilars and high-quality biologics

Spec Description
Dimensions (D x W x H) 48.5 x 46.5 x 32.5 cm
Net Weight 35 kg
Operating Conditions Indoor use only
Temperature: +10 °C to 40 °C
Humidity: 20% to 80% non-condensing
Altitude: Up to 2000M
Mains Supply: +/- 10% rated voltage
Electrical Supply Power Supply Input Voltage: 100-240V AV 50-60Hz Single Phase
Power Supply Output Voltage: 24V DC – 250W
Power Supply Input Connection: IEC Input

ICON Titer Plates

Compatible with ICON, ready to use, 96-well assay plates for IgG quantification.

  • RS-3221 ICON Titer Assay Plate – Plate based IgG assay for cloning plates. Five plates, each for 96 well samples. For 2.5 mg/L – 100 mg/L.
  • RS-3223 ICON Titer PLUS Assay Plate – Plate based IgG assay. Five plates each for 96 well samples. For 100 mg/L – 1500 mg/L.

ICON Cell Counting Slides

ICON offers automated cell counting and viability measurements for cells in suspension, enabling between 1 and 24 counts in a single run.

  • RS-3010 ICON Cell Counting Slides (8 counts per slides x 15 slides in box); 15 x Cell Counting slide for 8 counts each using 20 μl cell suspension.

STUDIUS™

The smartest decision-making platform in cell line development.

View Product

InstiSHAKE™

InstiSHAKE CHO and InstiSHAKE HEK as a follow on supplement in the transition to deep well plates.

View Product

ICON is the perfect choice for:

  • Cell line development for biologics
Solentim Cell Metric® X
Clonal imager with automated assurance

Simplify clonal assurance with Artificial Intelligence

Learn more
Solentim VIPS® PRO
High efficiency, single cell seeding and imaging platform

High efficiency, single cell seeding with image-based proof of clonality for GMP-compatible workflows

Learn more
STUDIUS™
Data management software platform

Data management for the highest level of consistency across the CLD workflow

Learn more

Services

Protect your investment with an Advanced Care service agreement from Advanced Instruments. Take the worry out of service costs and have total peace of mind knowing that your instrument is covered.

Learn more
Webinar

Employing Tools Of ICON To Advance Selection Of The Highest Producing Clones

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Scientific Poster

Improving Cell Line Development Processes Through Accurate, Low Volume and Rapid Automated Cell Counting and Viability on the ICON™ Instrument Using STUDIUS™ Data Management Software

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Applicaton Note

How STUDIUS™ Is Changing Cell Line Development

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Want to see what the ICON can do for your workflow?

BOOK A VIRTUAL DEMO

Request pricing

For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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Please fill out this brief form to download this content. You can also get in touch with our sales team for product questions, arranging a product demonstration or obtaining a quotation at the phone numbers below:

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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Request a Virtual Demo

For a quotation, to arrange a demonstration, or for more information please contact us by phone or complete the form.

Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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