Whether your cell line produces the biotherapeutic or is the biotherapeutic, we’ve identified critical bottlenecks in the cell line development workflow and created unique instruments and reagents that save time and advance your program while efficiently collecting critical IND-enabling data.

Delivering Speed and Confidence in Your CLD Workflow

From single-cell cloning and colony outgrowth to the establishment of a master cell bank, our portfolio of technologies and cell growth supplements and matrices deliver accelerated workflows while confidently ensuring clonality. Gain data-driven insights earlier, and track clones by leveraging a powerful data analysis and management platform. Now with solutions to support GMP-certification.

Solentim Ecosystem

Enhancing this workflow is the Solentim Ecosystem, featuring:

  • VIPS® PRO: Single cell seeder and imager
  • Cell Metric® X: Clone verification and colony outgrowth monitoring
  • ICON™: Clone productivity and quality assessment

These instruments, powered by the STUDIUS­™ Data Management Platform, provide robust and innovative solutions for biotherapeutic production, offering powerful data insights and enhanced efficiency to accelerate the path to IND submission without compromising quality.

High efficiency, single cell seeding and imaging platform


Cell Metric X
Clonal imager with
automated assurance


Clone & Protein
Biologic Analyzer


Data Management
Software Platform


Cell Growth Supplements


Leading Solutions for Cell Line Development

Built for cell line development

The Solentim® Ecosystem of CLD instruments has been created specifically for those needing robust, innovative solutions for single cell cloning workflows. Working together, our instruments unlock powerful data insights and drive efficiencies that have never been possible before.

Quality data for confident FDA submissions

If an IND submission is in your future, it is critical to anticipate the data that will be needed as part of your submission. The Solentim Ecosystem was built to capture high quality image-based proof and data analysis which provides concrete evidence of clonality throughout the CLD process.

Added efficiency to accelerate your workflow

Whether you have a GMP clinical workflow or are performing research, our solutions are designed to increase your efficiency. Get from single cell to master cell bank faster with tools to help you make better data-driven decisions earlier in the process.

Comprehensive & expert service offerings

We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, validation, training and maintenance of your osmometers to avoid disruptions to your work.

What our customers say

Before this instrument, all our clonal analysis was done manually. We used to spend hours on the microscope looking for wells containing colonies possibly derived from single cells. Now, everything is automated, we since we can track the cell growth over time, we can be absolutely sure that a particular clones is derived from a single cell.

Rodrigo Santos

Horizon Discovery

Very easy to use and produces good quality cell images, which are essential when monitoring outgrowth after limiting dilutions. The 10 plate cassette with automatic loading is very helpful for high throughput experiments, and the versatility of plate type makes the cell metric even more useful.

Ngarangi Mason

Horizon Discovery

The Cell Metric was designed with the end user in mind. Setup and use are easy and the ability to generate a clonality report at the end of a project is fantastic. I would highly recommend taking a very close look at the Cell Metric before adding any imaging system to a CLD workflow.

Ray Davis

RuffLife Consulting

The Solentim Cell metric has become a crucial instrument in our cell line development process. The instrument has allowed us to create reliable and consistent data which in turn results in us being able to track our cell lines and compare them to each other with ease. Images produced by this instrument are always of high quality, and it is easy to train new member of the team on this platform as the system is very user-friendly! ...The instrument is certainly worth the money we paid as it has allowed us to determine monoclonality and track colony growth ...

Emily Agro

Ultragenyx Pharmaceuticals

During expansion, we use InstiSHAKE CHO to support the adaptation of our clones to shaking culture. Thanks to InstiSHAKE CHO, we have significantly reduced the number of clones lost (by 90%) and have reduced the amount of time taken for cells to reach our desired viable cell density and viability by 7 days.  Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 


We use InstiGRO CHO to improve the efficiency of our cloning projects. The supplement has helped us achieve clonal outgrowth >80% and has reduced the time taken for clones to reach our desired confluence by 2 weeks! Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 


[With the VIPS PRO], we can trace back the data to the single cell, select from our top 48 cell lines, and report all the information – our proof of monoclonality is already in there, and that’s really nice.

Jolanda Gerritsen


The Enhanced Clonality Reports easily generated by the VIPS/Cell Metric software allows us to track both cells and potential debris from first inception of the single cell in the well, to full-grown colonies enabling us to provide our customers with full traceability and audit trail of each cell line we produce for them with a single, well-crafted document.

Camile Evenou

Celonic AG

The VIPS™ is unique, being the only single cell cloning system on the market that tracks a single cell’s arrival in the actual well with high resolution (z-stack) imaging and to support the subsequent daily whole well imaging provided by the Cell Metric.

Camile Evenou

Celonic AG

The VIPS system allowed us to shave off a few months from our development timeline and select highly stable single clones for manufacturing purposes.

Andy Tsun

Discovery Biology, Biotheus Inc.

The VIPS™ system and software has helped our company to deliver a high-quality data-package that meets global regulatory standards...The ease of use and reliability of the VIPS freed up valuable time.

Andy Tsun

Discovery Biology, Biotheus Inc.

Cell Metric had the best whole-well imaging capabilities and clonality reports and, when we demoed the instrument, we were convinced by the robustness of the system and very high image quality.

Tom Kelly


The Solentim ecosystem, [VIPS , Cell Metric, ICON], allowed Wheeler to rapidly develop and launch a standardized cell line development service that is integrated with a scalable drug substance process.

Mike Brem

Wheeler Bio

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