We accelerate cell line development workflows from initial discovery to scale-up and manufacturing of new biological therapies
From single-cell cloning and colony outgrowth to the establishment of a master cell bank, cell line development technologies from Advanced Instruments streamline the collection of evidence for credible IND submissions.
Streamlining Key Steps
When you’re bringing a biotherapeutic to market, finding the optimal cell line and ensuring clonality are critical for success, whether the cell line produces the biotherapeutic or is the biotherapeutic.
At Advanced Instruments, we’ve identified critical bottlenecks in the cell line development workflow and created unique instruments and reagents that save time and advance your program while efficiently collecting key IND-enabling data.
Efficiently Ensuring Clonality
Move beyond limiting dilution methods to gentle, imaging-assured single cell seeding with the Solentim VIPS® VIPS® PRO instrument. Combining low-pressure single cell seeding with whole-well imaging, VIPS simplifies cell line development workflows while gathering credible data for IND submission.
Alternatively, you can image individual plates with the stand-alone Solentim Cell Metric® X instrument. The Cell Metric X identifies single-cell clones on day 0 with artificial intelligence-based Automated Evidence of Clonality (AEC) and move from testing to IND submission weeks faster and delivers a clonality report that defines best practice for master cell bank production.
Accelerating Ranking and Selection of High Producing Clones
Make informed decisions faster and more securely when you combine the Solentim ICON™ with STUDIUS™.
ICON is a single, multifunctional instrument that enables the triage of clones via low volume titer and viable cell assays. ICON can integrate with STUDIUS for complete analysis of cell line development data.
Demonstrating monoclonality has never been more reliable and straightforward. No more ambiguity, no more ghost cells. Both our clients and our own scientists are very pleased with the data the VIPS instrument generates
Ferenc Boldog, Director of Cell Line Development ATUM, San Francisco
Popular Educational Resources
Learn more about how our technologies enhance your cell line development workflow by checking out our educational resources below
Associated Products
Solentim VIPS® PRO
High efficiency, single cell seeding with image-based proof of clonality for GMP-compatible workflows
Solentim ICON™
Maximize productivity by assessing titer and viability with a single instrument
Solentim STUDIUS™
Data management for the highest level of consistency across the CLD workflow
Next Generation Cell Culture Growth Supplements
Animal component-free cell culture supplements for CHO and HEK cells
Bioprocessing Services
Get the best performance from your osmometers and cell line development instruments from the people who designed and built them. We provide a range of services and service plans to meet the different needs of our customers.
Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your Advanced Instruments products.
