For many in biologics process development and manufacturing, knowing that your work saves lives, improves health, and alleviates suffering fuels a commitment to quality. But there are times when ensuring quality can feel like it conflicts with the need for speed and efficiency.
Not all osmometers can deliver the same accuracy, precision and speed as those from Advanced Instruments
At Advanced Instruments, we believe that quality and productivity go hand-in-hand and have built a family of products and services to help biologics manufacturers and process developers ensure the yield, purity, and consistency of biopharmaceutical products through osmolality testing..
Whether you need to maintain optimal cell growth, ensure active pharmaceutical ingredient (API) purity and yield, or confirm quality during fill and finishing, we offer an advanced osmometer that will keep your processes productive and on track, saving time and reducing costly re-work.
Applications
Medical lab instruments that deliver accuracy and efficiency
For laboratories seeking premium, reliable osmometers that meet their everyday needs for workflow efficiency, patient results security and integrity, connectivity, quality control, and compliance with CAP and CLIA guidelines , Advanced Instruments Osmometers are the right choice.
Keep your labs running smoothly and in compliance with osmometers that use the industry preferred freezing point depression method to provide accurate patient results.
Clinical Osmometer Applications
Advanced Instruments Osmometers can improve your workflow and increase efficiency in a wide variety of fields.
Application Notes & Whitepapers:
- Scientific Literature Review: The Importance of Measuring Osmolality in Monitoring and Managing COVID-19 Patients
- The Value of Osmolality Testing, Dr. Neville R. Dossabhoy
- The Value of Osmolality Testing in Emergency Medicine, Dr. David Schindler
- The Value of Osmolality Testing in Nephrology, Dr. Namrata Sharma Goel
- Osmometry Revisited, A Practical Guide to Its Clinical Use, David H. Lobdell, M.D.
- Clinical Osmometer Applications
Streamline workflow, save money and improve the quality and consistency of your bacterial cultivation. Automatically and easily create exact, repeatable environments to keep clinical labs productive so patients can potentially get treated faster and spend less time in the hospital.
With the Anoxomat anaerobic jar system by Advanced Instruments, you’ll get the flexibility to simultaneously maintain multiple types of anaerobic, micro-aerophilic, and capnophilic environments on your benchtop for fast and reliable bacterial growth and larger colonies.
The Anoxomat system speeds sample processing with the ability to move plates into and out of the micro-environment within minutes instead of the hours it takes with full-sized vacuum systems and anaerobic chambers. Everyone in the lab can accomplish more with Anoxomat.
Scientific Resource
Related Articles
- Summanen P, McTeague M, Väisänen M, Strong C, Finegold S. Comparison of recovery of anaerobic bacteria using the Anoxomat, Anaerobic Chamber, and GasPak Jar systems. Anaerobe 1999; 5:5-9
- Shanin M, Jamal W, Veghese T, Rotimi V. Comparative evaluation of Anoxomat and conventional anaerobic GasPak jar systems for the isolation of anaerobic bacteria. Medical Principles and Practice 2003; 12: 81-86
- Barenfanger J. Outcomes of improved anaerobic techniques in clinical microbiology. Clinical Infectious Diseases 2002; 35 (Supplement 1): S78-83
- McIntosh J, Bullock W. A new apparatus for the isolation and cultivation of anaerobic micro-organisms. The Lancet 1916; 87:768-770
Busy labs often look to automation to ensure timely sample processing, but analyzing CSF samples – especially those at clinically relevant low cell counts – can be time-consuming and challenging. For labs that want to improve results consistency and turnaround time, there’s an Advanced Solution that meets this need with GloCyte.
Our CSF cell counter automates handling of all CSF samples, detecting down to 1 cell/µL and delivering total nucleated cell (TNC) and red blood cell (RBC) results in less than 5-minutes using only 30 µL per test, GloCyte gives labs a reliable and efficient method for automating analysis of all CSF specimens.
See all CSF Cell Counting products
References
- Malenke, K. Cerebral Spinal Fluid Testing: Current methods for CSF analysis and new cell count technology. Advance for the Administrators of the Laboratory. December 2016. Vol. 25(12):p 16.
Bring accurate and reliable total and direct neonatal bilirubin testing to any facility with the BR2 Bilirubin Stat Analyzer and Bilirubin Test Kit. The compact, portable design easily fits into any facility, whether it is a dedicated medical lab or a pediatrician’s office, and the low 30 µL sample volume requirement facilitates analysis of samples from neonates.
Popular Educational Resources
Not all osmometers can deliver the same accuracy, precision, and speed as the ones from Advanced Instruments. In the resources below you can learn more about the power of measuring osmolality and why the freezing point depression method used in all of Advanced Instruments’ osmometers is considered the industry’s gold standard.
Osmometers For Biotech
Comparison Guide
All models supportPharmacopeia testing guidelines |
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| Workflow Features | |||||
| Best for labs with daily sample processing needs of: | >20/day | >10/day | 1-10/day | 1-10/day | 1-10/day |
| Sample volume | 40 µL | 30 µL | 20 µL | 20 µL | 250 µL |
| Sample introduction | 96 well plate | Sample cup | One-step direct | One-step direct | Sample cup |
| Operating range (mOsm/kg H2O) | 0 – 2,000 mOsm/kg H2O | 0 – 2,000 mOsm/kg H2O | 0 – 4,000 mOsm/kg H2O | 0 – 2,000 mOsm/kg H2O | 0 – 4,000 |
| Test time (seconds) | 140 | 90 | Less than 150 in low range, Less than 190 in high range | 90 | 120 |
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| Automated cleaning between samples | |
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| Complex Matrices (High Concentrations, Sugars, & Proteins) | |
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| Integrated barcode scanner |  |
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| Onboard Video Instructions | |
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| Multi-language touchscreen display | |
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| Compliance Support Features | |||||
| Supports 21 CFR Part 11 & EU Annex 11 compliance | |
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| Electronic Signature (Review & Approve) | |
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| Supports Pharmacopeia testing guidelines compliance | |
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| Instrument Features | |||||
| Username & Password Compatibility (With Active Directory) | |
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| Dot-matrix Printer | |
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| Network Connection | |
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| Network share | |
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| Automatic backup | |
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| Control device remotely via OPC-UA | |
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| USB | |
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| Webserver for remote data viewing | |
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| Data Storage Capacity | Unlimited | Unlimited | Unlimited | Unlimited | |
| Levels of users access | 3 Levels | 3 Levels | 3 Levels | 3 Levels | |
| Data Format | .csv & pdf | .csv & pdf | .csv & pdf | .csv & pdf | |
| Part # | OSMOTECHHT | OsmoTECHPRO | OsmoTECHXT | OsmoTECH | 3250 |
Download Chart as a PDF
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Biotech Services
Get the best performance from your osmometer from the people who designed and built it. We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your osmometers.
Calibrators & Controls
Calibration Standards for Osmometers
A wide range of Advanced Instruments Calibration Standards are available and designed to accurately calibrate our full line of Advanced® osmometers at specific levels.
Protinol™ Protein-Based Controls
Protinol is a line of protein-based serum osmometer control solutions, specifically formulated at three relevant decision levels.
Clinitrol 290 Reference Solution
Use Clinitrol 290 Reference Solution to verify system calibration and as a daily system check to strengthen your laboratory’s quality control program.
Anaerobic Jar Systems
Anoxomat® III Anaerobic Jar System
The Anoxomat III anaerobic jar system is an efficient method of bacterial cultivation, creating repeatable environmental conditions for the biotechnology microbiology laboratory. Using the evacuation and replacement method of McIntosh & Fildes, the Anoxomat can create anaerobic, microaerophilic, or custom environments, such as capnophilic. Anoxomat’s easy operation and its built-in quality assurance program guarantees reliable results.
Standard Jars for Anoxomat
Anoxomat® Standard jars are available in a variety of sizes. The system capacity can be updated and expanded at any time — according to your laboratory’s needs.
Ergonomic Jars for Anoxomat
Our ergonomic anaerobic jars provide flexibility and ease-of-use for laboratory technicians while maximizing incubator and laboratory space. All Anoxomat jars are built to meet the highest microbiological and mechanical standards and minimize the risk of oxygen leaks.
Palladox™ Disposable Sachet
The new single use Palladox disposable sachet is designed specifically to work with the Anoxomat System, improving workflow efficiency and simplifying anaerobic culturing. The easy-to-use, single-use catalyst will simplify your anaerobic sample testing by minimizing catalyst handling time. The Palladox sachet reduces the oxygen in the jar in minutes and maintains an anaerobic environment for the duration of incubation.
The Osmo1 osmometer is a very simple to use osmometer. The instrument is reliable, robust, accurate and very fast at collecting data. Overall it is a high quality instrument, accurate results, easy to use.
Haileab Ghebrekidan, Macrogenics
Popular Educational Resources
The Value of Osmolality Testing in Clinical Chemistry
Osmolality is a fundamental measurement of the total solute concentration of body fluids. It is a valuable clinical diagnostic tool.
CSF Cell Counting - an evaluation of the GloCyte system
Laboratory staff face many decisions when they encounter a cerbrospinal fluid specimen. Learn more about how the GloCyte CSF Cell Counter system performs.
Scientific Resource
The Anoxomat III Anaerobic Jar System gives superior results compared to gaspak sachet generating methods.
Osmometers For Clinical
All models support:
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| Best for labs with daily sample processing needs of: | >10/day | >10/day | 1-10/day | |
| Sample volume | 100 µL | 20 µL | 20 µL | |
| Sample introduction | Automated liquid handling | Sample cup | One-step direct sampling | |
| Operating range (mOsm/kg H2O) | 0 – 4,000 | 0 – 2,000 | 0 – 2,000 | |
| Test time (seconds) | 180 | 90 | 90 | |
| Compliance Support Features | ||||
| Supports CAP & CLIA compliance |  |
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| Supports HIPAA compliance | |
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| Instrument Features | ||||
| Integrated barcode scanner | |
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| On-board printer | |
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| Multi-language touchscreen display | |
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| Automated cleaning between samples | |
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| Automated sample pipetting | |
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| Temperature control method | Dry cooling (No heat-transfer fluid) | Dry cooling (No heat-transfer fluid) | Dry cooling (No heat-transfer fluid) | |
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| LIS Connectivity | |
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| USB | |
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| Part # | A2O | OsmoPRO | Osmo1 | |
| Learn More Request Pricing |
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The most reliable osmometer we've ever used. We recently purchased another unit. Maintenance is easy, quick, saves time. Very economical, QC's are always good including the standard 290 (within range, every run).
Maria Baquiran, VAMC
Clinical Services
Get the best performance from your instrument from the people who designed and built it. We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, training, validation, and maintenance of your osmometers, anaerobic jar systems, and neonatal bilirubin stat analyzers.
Calibrators & Controls
Protinol™ Protein-based Controls
Manufacturer-recommended QC helps labs stay within CAP & CLIA regulation guidelines.
Renol™ Urine Osmolality Controls
Manufacturer-recommended QC helps labs stay within CAP & CLIA regulation guidelines.
Clinitrol 290 Reference Solution
Use Clinitrol to verify system calibration and as a daily system check to strengthen your laboratory’s quality control program.
Anaerobic Jar Systems
Anoxomat® III Jar System
This anaerobic jar system easily creates custom anaerobic and microaerophilic environments in as little as 5 minutes, achieving effective and rapid bacterial recovery in less time. It allows clinical microbiology labs to realize cost savings, increased productivity and improved workflow.
Palladox™ Disposable Sachet
The new single use Palladox disposable sachet is designed specifically to work with the Anoxomat System. The easy-to-use, catalyst will simplify your anaerobic sample testing by minimizing catalyst handling time.
Ergonomic Jars for Anoxomat
Our light-weight, Ergonomic jars, provide flexibility and ease-of-use for lab techs, while maximizing incubator and laboratory space.
CSF Cell Counters
GloCyte
GloCyte is the automated cell counter that can handle all CSF specimens – even those with clinically relevant low cell counts that fall below the linearity of other automated analyzers.
GloCyte improves result consistency and turnaround time compared to the manual hemocytometer method.
Neonatal Bilirubin Testing
BR2 Bilirubin STAT-Analyzer
The Advanced® BR2 Bilirubin Stat-Analyzer™ system provides fast, accurate results for both total and direct bilirubin levels in neonates requiring only a 30µL serum or plasma sample. Ideally suited for pediatric physician offices, hospital stat labs, or pediatric research laboratories.
