Bioprocessing Osmometers

Whether you need insight into process development, patient health, or product quality, Advanced Instruments osmometers deliver unmatched quality, performance, and reliability.

Our easy-to-use instruments are thoughtfully optimized for bioprocessing and readily fit into any workflow and include a range of connectivity options.

We’ll help you determine the right model for your needs – no matter which model you choose, you’ll get the speed and precision of freezing point technology – the gold standard osmolality measurement method – from the osmometer manufacturer you can count on for all of your osmolality needs.

Portfolio Brochure

Clinical Osmometers

How Can Osmometers Help in The Bioprocessing Workflow?

Biopharmaceutical labs using routine osmolality testing can have confidence in their processes during the development and manufacturing of biologic drugs while also having better control over the titer, yield, quality, and purity of their product. Learn more about biotech applications of osmolality here.

OsmoTECH^® HT Automated Micro-Osmometer Learn more

OsmoTECH^® PRO Multi-Sample Micro-Osmometer Learn more

OsmoTECH^® XT Single-Sample Micro-Osmometer Learn more

Why Are Advanced Instruments Osmometers The Best Fit For The Biotech Industry?

Trusted and Reliable performance

Over 65 years of experience in developing and manufacturing freezing point depression technology across the biopharmaceutical market. The OsmoTECH portfolio of osmometers offers superior performance across a diverse range of samples, osmolalities, and applications.

Robust Data compliance & management

Data integrity is paramount to ensuring the validity of the data and its analyses. Advanced Instruments osmometers help allow customers to meet the strict data integrity requirements of 21 CFR part 11 and EU Annex 11.

Scalable and Easy to integrate

The bioprocessing workflow is complex and multifaceted, which leads to a varying set of requirements depending on the stage where a customer is located. Designed in close collaboration with customers, the OsmoTECH portfolio of osmometers perfectly meets their requirements and can be easily integrated into the workflow to get their lab ready to go.

Comprehensive & Expert Service offerings

We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, validation, training and maintenance of your osmometers to avoid disruptions to your valuable work.

“The instrument has been reliable and accurate. Advanced Instruments customer service and tech support is outstanding…one of the best vendors I deal with.”

“Great instrument with easy operation. Product is worth it. It is super easy to use and gives consistent results.”

“We would never go back to the older models of osmometers after using this one. This is a great instrument with very reliable results.”

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Selection Guide

All models support Pharmacopeia testing guidelines. Download Chart as PDF	New! OsmoTECH^® HT Automated Micro-Osmometer Request Pricing Request a virtual demo	OsmoTECH^® PRO Multi-Sample Micro-Osmometer Request Pricing Request a virtual demo	OsmoTECH^® XT Single-Sample Micro-Osmometer Request Pricing Request a virtual demo	OsmoTECH^® Single-Sample Micro-Osmometer Request Pricing Request a virtual demo	Being discontinued Dec. 31, 2020 Model 3250 Single- Sample Osmometer Request Pricing Request a virtual demo
Workflow Features
Best for labs with daily sample processing needs of:	>20/day	>10/day	1-10/day	1-10/day	1-10/day
Sample volume	40 µL	30 µL	20 µL	20 µL	250 µL
Sample introduction	96 well plate	Sample cup	One-step direct	One-step direct	Sample cup
Operating range (mOsm/kg H₂O)	0 – 2,000 mOsm/kg H₂O	0 – 2,000 mOsm/kg H₂O	0 – 4,000 mOsm/kg H₂O	0 – 2,000 mOsm/kg H₂O	0 – 4,000 mOsm/kg H₂O
Test time (seconds)	140	90	Less than 150 in low range, Less than 190 in high range	90	120
Multi-sample capacity
Automated cleaning between samples
Complex Matrices (High Concentrations, Sugars, & Proteins)
Integrated barcode scanner	₁				₁
Onboard Video Instructions
Multi-language touchscreen display
Compliance Support Features
Supports 21 CFR part 11 & EU Annex 11 compliance
Supports Pharmacopeia testing guidelines compliance
Electronic Signature (Review & Approve)
Username & Password Compatibility (With Active Directory)
Levels of users access	3 Levels	3 Levels	3 Levels	3 Levels
Data Management
Network Connection
Network share				₂
Automatic backup
Control device remotely via OPC-UA
USB
Webserver for remote data viewing
Levels of users access	3 Levels	3 Levels	3 Levels	3 Levels
Data Storage	Unlimited	Unlimited	Unlimited	Unlimited
Part #	OsmoTECHHT	OsmoTECHPRO	OsmoTECHXT	OsmoTECH	3250
Dot-matrix printer	₁	₁	₁	₁
Download Chart as PDF	Learn More	Learn More	Learn More	Learn More	Learn More