Bioprocessing Osmometers

Built for Bioprocessing

Whether you need insight into process development, patient health, or product quality, our osmometers deliver unmatched quality, performance, and reliability.

Our entire portfolio of OsmoTECH® osmometers provide you with the speed and precision of freezing point technology.

Each of our easy-to-use instruments is thoughtfully optimized for bioprocessing and readily fits into any workflow from process development through GMP manufacturing.

How Can Osmometers Help in The Bioprocessing Workflow?

Biopharmaceutical labs using routine osmolality testing can have confidence in their processes during the development and manufacturing of biologic drugs while also having better control over the titer, yield, quality, and purity of their product. Learn more about biotech applications of osmolality here.

Why Are Our Osmometers The Best Fit For The Biotech Industry?

Trusted and Reliable performance

Over 65 years of experience in developing and manufacturing freezing point depression technology across the biopharmaceutical market. The OsmoTECH portfolio of osmometers offers superior performance across a diverse range of samples, osmolalities, and applications.

Robust Data compliance & management

Data integrity is paramount to ensuring the validity of the data and its analyses. Our osmometers help allow customers to meet the strict data integrity requirements of 21 CFR part 11 and EU Annex 11.

Scalable and Easy to integrate

The bioprocessing workflow is complex and multifaceted, which leads to a varying set of requirements depending on the stage where a customer is located. Designed in close collaboration with customers, the OsmoTECH portfolio of osmometers perfectly meets their requirements and can be easily integrated into the workflow to get their lab ready to go.

Comprehensive & Expert Service offerings

We provide a range of services and service plans to meet the different needs of our customers. Our certified Field Service Engineers provide on-site professional support for the installation, validation, training and maintenance of your osmometers to avoid disruptions to your valuable work.

Choose The Right Advanced Instruments Osmometer For Your Needs

All models support Pharmacopeia testing guidelines. Download Chart as PDF	OsmoTECH^® HT Automated Micro-Osmometer Request Pricing Request a virtual demo	OsmoTECH^® Pro Automated Micro-Osmometer Request Pricing Request a virtual demo	OsmoTECH^® XT Single-Sample Micro-Osmometer Request Pricing Request a virtual demo
Workflow Features
Best for labs with daily sample processing needs of:	>20/day	>10/day	1-10/day
Sample volume	40 µL	30 µL	20 µL
Sample introduction	96 well plate	Sample cup	One-step direct
Operating range (mOsm/kg H₂O)	0 – 2,000 mOsm/kg H₂O	0 – 2,000 mOsm/kg H₂O	0 – 4,000 mOsm/kg H₂O
Test time (seconds)	140	90	Less than 150 in low range, Less than 190 in high range
Multi-sample capacity
Automated cleaning between samples
Complex Matrices (High Concentrations, Sugars, & Proteins)
Integrated barcode scanner	¹
Onboard Video Instructions
Multi-language touchscreen display
Compliance Support Features
Supports 21 CFR part 11 & EU Annex 11 compliance
Supports Pharmacopeia testing guidelines compliance
Electronic Signature (Review & Approve)
Username & Password Compatibility (With Active Directory)
Levels of users access	3 Levels	3 Levels	3 Levels
Data Management
Network Connection
Network share
Automatic backup
Control device remotely via OPC-UA
USB
Webserver for remote data viewing
Data Storage Capacity	Unlimited	Unlimited	Unlimited
Data format	.csv & PDF	.csv & pdf	.csv & pdf
Part #	OsmoTECHHT	OsmoTECHPRO	OsmoTECHXT
Dot-matrix printer	₁	₁	₁
Download Chart as PDF	Learn More	Learn More	Learn More

1. Sold separately

DOWNLOAD CHART AS PDF

What our customers say

We had a demo of the [OsmoTECH PRO] instrument after seeing it at BPI East. The sales managers were prompt in setting up a lunch and learn. The instrument itself was very easy to run samples on and allowed for true load and walk away functionality. The sales managers were thorough professionals, waiting for our PO to go through and working with us to ensure we received the item within a week of ordering. It has the ability to run 20 samples at a time and is great value for the money spent.

Kanaka Bhere

Boehringer Ingelheim Animal Health

The [OsmoTECH PRO] instrument is extremely effective, easy to set up and validate, gives quick results and is extremely accurate.

David Longino

Aspek Pak

The [OsmoTECH PRO] is great for accurate and precise osmolality, giving reliable and reproducible measurements.

Varun Khurana

Glaukos

This [OsmoTECH] instrument was a dream come true. The administrator can lock down features and dictate what users can and cannot do. Very easy to use and extremely reliable instrument.

Troy Franz

Paragon Bioservices

The best part of the [OsmoTECH] instrument is it gives accurate and reproducible results for any solution and most importantly in less than a minute you have the results.

Brijeshkumar Pandya

Nivagen Pharmaceuticals Inc.

[The OsmoTECH] achieves high quality and reproducible results. Easy instrument to use and well-presented software.

Claudia Chadford

Touchlight Genetics

[The OsmoTECH PRO] instrument is simple to operate with minimal consumables.

Greg Hautke

Baxter Healthcare

This [OsmoTECH PRO] osmometer is an accurate and convenient tool for the needs of our lab. Our lab works in the developmental stage of pharmaceuticals, and requires quick, precise bursts of osmolality checking for QC - and this instrument (with a load capacity of 20 samples) takes care of those needs. With developmental drugs, limited sample volume is often an issue - this instrument only needs 30uL (and takes ~90 seconds a measurement).

Sasha Sheptovitsky

Alexion Pharmaceuticals

Osmolality measurements are easy and reliable with this [OsmoTECH PRO] instrument.

Kevin Kent

Boehringer-ingelheim

[The OsmoTECH PRO is] very easy to use for all technicians in a quality control lab. Small sample size. Friendly technicians that explained how to use the product very well.

Cathy Gladkowski

Biologos LLC

[The OsmoTECH PRO is] very easy to use due to short analysis time and sample preparation.

Karthik Venkatachalam

Pfizer

[The OsmoTECH PRO is a] great system for multiple sample testing. Very straightforward and easy to use.

Bobby Grigoropoulos

Fresenius Kabi USA

[The OsmoTECH XT is] easy to use, reliable and self-navigating options menu.

Alexander Shapiro

Precision NanoSystems

The OsmoTECH PRO is working pretty well so far! ... As far as reproducibility, data integrity, ease of use etc. I think it is a very good upgrade for us! On the whole we’re quite happy, I'd recommend this device to a colleague looking for a new high throughput osmometer.

Sean Clements

Takeda

The [OsmoTECH] is highly effective and obtained results are of high quality. With this instrument I can develop my formulation for meeting the osmolality criteria for drug products.

Siva Bingi

Intas Pharmaceuticals

[The OsmoTECH is] easy to use and robust piece of equipment that met all our user and regulatory requirements. The hardware is sleek, efficient and easy to use. The integrated software has built in data integrity controls and is thoroughly tested through validation test scripts / reports.

J. Lacey

Replimune

Equipment was easy to set up and easy to use. The [OsmoTECH HT] runs reliably and is great to have for running many samples.

Monica G

Biotech

[The OsmoTECH PRO is an] excellent product and extremely efficient! Easy to clean and maintain. Excellent customer support and allows increased in-process testing capabilities.

Seth Rindner

Biologos LLC

The [OsmoTECH PRO] is very easy to use. Allows my lab to update a 20+ year old instrument, also from Advanced.

Walter Wasylenko

Baxter Healthcare Corporation

[The OsmoTECH XT is a] robust and versatile instrument that meets all of our osmolality needs!

Will Heaton

DiscGenics

In the beginning, you never know which kind of samples you’re going to test, and the [OsmoTECH XT] osmometer offers an amazing range of osmolality testing: from 0 to 4000 mOsm/kg H₂O.

Kayla Pasake

The Center for Breakthrough Medicines

Osmolality testing is crucial for process development, analytical development and GMP testing. We need to meet the regulatory requirements [with the OsmoTECH XT] for the product to be released to the market or to be released to go to a patient.

Kayla Pasake

The Center for Breakthrough Medicines

Compliance & Conformity

Compliance & Conformity

Built for Bioprocessing

Features Support Your Workflow

How Can Osmometers Help in The Bioprocessing Workflow?

OsmoTECH® XT Single-Sample Osmometer

OsmoTECH® PRO Multi-Sample Micro-Osmometer

OsmoTECH® HT Automated Micro-Osmometer

Bioprocess Calibrators and Controls