DMSO QualAssure®

Simplify the verification of low-volume DMSO dispenses and improves the validity of HTS assays

Validate your liquid transfers whenever dimethyl sulfoxide solvent is used

DMSO has very different physical properties than water it behaves differently when handled by air-displacement pipettors or acoustic droplet ejectors, creating the need for a solvent-specific volume verification method such as that provided by the new DMSO Range E Solution for the MVS. DMSO-based Sample Solutions Will Help You: - Ensure concentrations of compounds in assay plates by measuring nL volumes of 100% DMSO - Measure performance of acoustic dispensing systems and other low-volume liquid dispensers - Standardize nL volume delivery across liquid handler types with DMSO- and aqueous-based solutions

Highlighted features
  • Convenient
  • Easy-to-Use
  • Designed specifically for Artel MVS

Dimethyl sulfoxide (DMSO) has become one of the most important solvents used for high-throughput screening (HTS) and compound management applications due to its ability to readily dissolve a wide range of compounds. DMSO has very different physical properties than water it behaves differently when handled by air-displacement pipettors, automated liquid handlers or acoustic droplet ejectors, creating the need for a solvent-specific volume verification method such as that provided by the DMSO QualAssure for the MVS. The MVS DMSO QualAssure solutions can measure performance over a wide volume range of 0.0001 to 9.999 µL.

A 100% DMSO QualAsssure solution has been developed for use with the MVS. DMSO QualAssure is capable of measuring volumes down to 10 nL. As with all MVS QualAssure solutions, results are traceable to international standards.

Research has shown that the volumes dispensed during drug screening programs can have a significant effect on the results obtained by assay screens.1 Any error made during these deliveries affects the concentration of the drug candidate and can lead to misleading data about compound activity being generated.

Advanced Instruments has developed and characterized a 100% DMSO-based dye solution for use with the Artel MVS® Multichannel Verification System. This article discusses the challenges and performance capabilities of a DMSO-based dual-dye solution developed for the MVS. The DMSO-based solution is capable of measuring dispensed volumes as small as 10 nL. Data presented suggests that if two successive liquid transfers are inaccurate, critical reagent concentrations could be affected by as much as 50%.2

This data demonstrates that 100% DMSO E adds a significant capability to the MVS for measuring liquid handling instrument performance. This capability answers the need for those scientists working in the drug discovery arena for a fast and reliable method to verify that their liquid handling instruments are accurately and precisely dispensing DMSO-based solutions.

System Performance with 96 well MVS Verification Plate

Solution Range (μL) (Uncertainty) Inaccuracy(%) (Imprecision) CV (%)
DMSO C 9.999 to 2.000 1.46 to 1.63 0.15 to 0.20
DMSO D 1.999 to 1.000 1.38 to 1.61 0.16 to 0.19
DMSO E 0.9999 to 0.1000 1.39 to 2.87 0.16 to 0.22
0.0001 to 0.0999 (Non-traceable volume range) N/A N/A

System Performance with 384 well MVS Verification Plate

Solution Range (μL) (Uncertainty) Inaccuracy(%) (Imprecision) CV (%)
DMSO C 2.499 to 0.500 2.04 to 2.35 0.36 to 0.40
DMSO D 0.4999 to 0.3000 1.88 to 2.01 0.36 to 0.38
DMSO E 0.2999 to 0.0300 1.89 to 3.23 0.36 to 0.44
0.0299 to 0.0100 3.24 to 7.47 0.44 to 0.47
0.0001 to 0.0099 (Non-traceable volume range) N/A N/A
MVS® Multichannel Verification System

Simple volume verification with results in less than 10 minutes.

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MVS QualAssure® Solutions

Optimize your automated liquid handlers with the ideal liquid for your application.

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ArtelWare™ Software

Ensure your liquid handlers and pipettes are performing properly with full suite of management tools.

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Austria: +49 695 0606 800
Belgium: +31 6 899 25902
France: +33 456 681 861
Germany: +49 695 0606 800
The Netherlands: +31 6 899 25902
United Kingdom: +44 740 890 1366

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