Bioprocessing Industry

Cell Line Development

Enhance your cell line development workflows for successful IND submissions.

Accelerate cell line development workflows from initial discovery to the scale-up and manufacturing of new biological therapies

From single-cell cloning and colony outgrowth, to the establishment of a master cell bank, create credible IND submissions by streamlining your collection of evidence with our cell line development technologies.

Streamline Key Steps for Success

When you’re bringing a biotherapeutic to market, it’s critical to find the optimal cell line and ensure clonality, whether the cell line produces the biotherapeutic or is the biotherapeutic itself.

We’ve identified the critical bottlenecks in the cell line development workflow and created unique instruments and reagents that save you time and advance your program while collecting your critical IND-enabling data efficiently.

Ensure Clonality Efficiently

Our cell line development technology helps your teams move beyond limiting dilution methods to gentle, imaging-assured single cell seeding. By combining low-pressure single cell seeding with whole-well imaging, VIPS® PRO simplifies your cell line development workflows while gathering credible data for IND submissions at critical timepoints.

Significantly reduce your testing to IND submission time frame. The Cell Metric® X is the gold standard for high quality, whole-well images. Capable of high-throughput clonal imaging, with artificial intelligence-based Automated Evidence of Clonality (AEC) you can automate detection and identification, while collecting image-based proof of monoclonality.

Revolutionize Your Clone Selection Process with ICON­™

The ICON is an award-winning all-in-one solution for clonal screening, colony outgrowth & protein biologics characterization.

The ICON uses low-volume, high-throughput assays to measure titer and CQAs, which in combination with the integrated STUDIUS™ decision making platform, combines data to produce accurate clone triaging parameters to identify the best performing clones automatically, instantaneously, and without error.

Enhance Clonal Outgrowth

Optimize conditions to support early and robust cell growth when searching for high-value cells.

Our reagents products are proprietary animal-component-free cell culture supplements formulated to  confer major growth and survival advantages within your cell line development of CHO and HEK cells.

We designed the Solentim MatriClone™ matrix to support iPSC growth in single-seeding workflows while maintaining pluripotency. MatriClone is also optimized for ‘in-solution’ seeding and optically suited for automated imaging.

Improve Workflow Consistency and Reproducibility

We understand working with living specimens presents unique challenges, due to the intrinsic variability of your starting materials. Producing lot-to-lot consistency throughout the process is especially challenging with ultra-low liquid volumes.

But our technology and services can take the liquid handling errors out of the equation. Liquid volume verification helps you ensure that pipetted volumes are correct (even for volumes as low as 0.01µL) when prepping samples for your critical assays, such as qPCR, RT-PCR, NGS, ELISA, or HPLC.

Access our Popular Educational Resources

From case studies to webinars, find out more by checking out our comprehensive educational resources.

Cell Line Development Case Study

Reducing the timeline by 30% to produce a monoclonal cell line expressing a clinical candidate bi-specific antibody


Cell Line Development Case Study

Successfully filing an IND using Solentim’s VIPS™ single cell cloning system


Cell Line Development Case Study

Doubling the Speed of Cell Line Development in a Large Pharmaceutical Company


Cell Line Development App Note

Addressing Cell Line Development Bottlenecks Progressing from Conditioned Medium to InstiGRO Reagents


Cell Line Development App Note

Automated Evidence of Clonality


Cell Line Development App Note

VIPS® Updates: Product Improvements for an Increased Efficiency in Single-Cell Seeding Process


Cell Line Development Webinar

Increased Efficiency of Clonal Selections & CLD Workflows with Solentim ICON


Cell Line Development Webinar

Employing Tools of ICON to Advance Selection of the Highest Producing Clones


Cell Line Development Webinar

Healthy Cells, Healthy Results: How to Improve Cell Line Development


Cell Line Development Posters

Addressing CLD Pain Points, Creating Efficiencies and Accelerating Biotherapeutic Development with Advanced Instruments Ecosystem


Cell Line Development Posters

Product In Action - OsmoTECH® HT Automated Micro-Osmometer


Cell Line Development Posters

Solentim’s STUDIUS™ Powered Ecosystem - Clonality in Cell Line Development Workflows


Cell Line Development Knowledge Center

Assurance of Clonality


Cell Line Development Knowledge Center

Cell Line Development for Biotherapeutics


Cell Line Development Knowledge Center

Data Integrity


Associated Products

Our Support, Maintenance, and IQOQ Services

Get the best performance from your Solentim instruments from the experts who designed them. We provide a range of services and service plans to meet your specific needs.

Our certified Field Service Engineers are standing by to provide on-site, professional installation, training, validation, and maintenance support for your Advanced Instruments equipment.

Learn more

What our customers say

Cell Metric had the best whole-well imaging capabilities and clonality reports and, when we demoed the instrument, we were convinced by the robustness of the system and very high image quality.

Tom Kelly


The Solentim ecosystem, [VIPS , Cell Metric, ICON], allowed Wheeler to rapidly develop and launch a standardized cell line development service that is integrated with a scalable drug substance process.

Mike Brem

Wheeler Bio

[With the VIPS PRO], we can trace back the data to the single cell, select from our top 48 cell lines, and report all the information – our proof of monoclonality is already in there, and that’s really nice.

Jolanda Gerritsen


The VIPS™ system and software has helped our company to deliver a high-quality data-package that meets global regulatory standards...The ease of use and reliability of the VIPS freed up valuable time.

Andy Tsun

Discovery Biology, Biotheus Inc.

The VIPS™ is unique, being the only single cell cloning system on the market that tracks a single cell’s arrival in the actual well with high resolution (z-stack) imaging and to support the subsequent daily whole well imaging provided by the Cell Metric.

Camile Evenou

Celonic AG

Before this instrument, all our clonal analysis was done manually. We used to spend hours on the microscope looking for wells containing colonies possibly derived from single cells. Now, everything is automated, we since we can track the cell growth over time, we can be absolutely sure that a particular clones is derived from a single cell.

Rodrigo Santos

Horizon Discovery

Very easy to use and produces good quality cell images, which are essential when monitoring outgrowth after limiting dilutions. The 10 plate cassette with automatic loading is very helpful for high throughput experiments, and the versatility of plate type makes the cell metric even more useful.

Ngarangi Mason

Horizon Discovery

The Cell Metric was designed with the end user in mind. Setup and use are easy and the ability to generate a clonality report at the end of a project is fantastic. I would highly recommend taking a very close look at the Cell Metric before adding any imaging system to a CLD workflow.

Ray Davis

RuffLife Consulting

The Solentim Cell metric has become a crucial instrument in our cell line development process. The instrument has allowed us to create reliable and consistent data which in turn results in us being able to track our cell lines and compare them to each other with ease. Images produced by this instrument are always of high quality, and it is easy to train new member of the team on this platform as the system is very user-friendly! ...The instrument is certainly worth the money we paid as it has allowed us to determine monoclonality and track colony growth ...

Emily Agro

Ultragenyx Pharmaceuticals

The Enhanced Clonality Reports easily generated by the VIPS/Cell Metric software allows us to track both cells and potential debris from first inception of the single cell in the well, to full-grown colonies enabling us to provide our customers with full traceability and audit trail of each cell line we produce for them with a single, well-crafted document.

Camile Evenou

Celonic AG

The VIPS system allowed us to shave off a few months from our development timeline and select highly stable single clones for manufacturing purposes.

Andy Tsun

Discovery Biology, Biotheus Inc.

During expansion, we use InstiSHAKE CHO to support the adaptation of our clones to shaking culture. Thanks to InstiSHAKE CHO, we have significantly reduced the number of clones lost (by 90%) and have reduced the amount of time taken for cells to reach our desired viable cell density and viability by 7 days.  Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 


We use InstiGRO CHO to improve the efficiency of our cloning projects. The supplement has helped us achieve clonal outgrowth >80% and has reduced the time taken for clones to reach our desired confluence by 2 weeks! Taken together, the combined use of InstiGRO CHO and InstiSHAKE CHO can accelerate our CLD workflow up to 3 weeks with little compromise to productivity. 


The Artel PCS makes checking the pipetting proficiency of new hires quick and easy. It's also great for checking pipettes that may not be functioning properly.

Eric M


The Artel MVS has been a huge help for our lab in validating volumes on new automated liquid handlers. Always gives consistent results, easy to use, software is extremely straightforward, and any time we have an issue, it's super easy to get help from the Artel team. Thank you!

Leah Chong


The MVS system is extremely useful for periodic performance QC testing of high-throughput liquid handlers, high-throughput liquid handler calibration, and various liquid handler/single channel pipette tip type/lot QC. The MVS system requires minimal maintenance and MVS manager software is intuitive to use and flexible to set up various plate layouts to meet user’s need. The customer service is very responsive and helpful. They provide a notification for calibrator plate re-certification annually ...

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The [Artel MVS] product is accurate and reliable. With the addition of the pre-owned models of MVS readers, it also becomes affordable. The expansion of the dye solutions to include MasterMix and Serum along with their original aqueous offering makes Artel a definitive liquid class setup solution. The FSE performing setup and the account manager were on-time, responsive, and supportive during install and (most importantly) afterwards.

Kevin Kim

Avellino Labs

The Artel application scientist is easy to work with, knowledgeable about interpreting test data and giving advice, and flexible to help onsite if needed. I would recommend the Artel MVS because it saves time and material cost. Most important is having a standard method to calibrate different pipettes and optimize liquid class on automated liquid handlers while managing the sources of variability systematically.

Michelle Mak

10x Genomics

Equipment was easy to set up and easy to use. The [OsmoTECH HT] runs reliably and is great to have for running many samples.

Monica G


The Artel PCS fulfills our requirements on ISO compliant pipette calibration and testing. Results are reproducible and variance is lower than in manual process. Personnel is easily trained on the device. Process is faster than manual process.

Andreas Heider

Axolabs GmbH

The MVS system is fairly intuitive to use. Not only can we use this for our internal automated liquid handler volume verification, tip test and calibration work, we have been using the system to offer external volume verification service to our collaborators. The system is very durable without significant issues and easy to maintain. MVS reagent orders are always processed and delivered in a timely manner. Our regional specialist periodically checks in to ask if the system is working as expected.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

The [Artel MVS] is easy to use, gives accurate and reliable results. It's a great way to quickly determine the functioning of the automation systems that we install and maintain.

Thobias Haakman

Beckman Coulter

The Artel MVS simplifies fluid verification of all automated liquid handlers and multichannel pipettes. The system is fast, calculates all plate and well statistics (Relative Inaccuracy, Coefficient of Variation, Standard Deviation and Mean) and it is simple to set up and use. For all of its capabilities and low-cost point...the MVS is one of the best value purchases I have ever made for my lab.

Mark Orlowski


The Artel MVS makes it so easy to do a monthly verification that the 96 channel CORE head on my Hamilton Vantage is dispensing the correct volumes. Doing the confirmation gravimetrically would be so time consuming, but using the Artel dyes and the MVS makes it something one person can do in a single morning. The software is easy to use, and the instrument has not had any maintenance issues.

Katherine Schneider


We use the PCS pipette calibration system. It has always been super reliable and accurate, and we have never had a single issue in the 8 years I have worked with it. The kits containing the solutions for the PCS are customizable, so you don't have to buy solutions you don't need. We do performance checks on our pipettes on a daily basis, so we could not live without it! It makes our jobs so much easier too!

Joan Kozlowski

Fresenius Kabi

Once we brought [the Artel MVS] into the lab, we realized we could push to small volumes. We typically work beyond the liquid handler’s specifications, and we can do this because we have Artel to verify their performance.

Robert Grbac


The Artel MVS System has greatly improved our laboratory quality processes, not only streamlining instrument qualifications but accelerating verification and validations.

Chris Trefill


We rely on the MVS for verifications and liquid class development and optimization…

Thai Truong

Janssen R&D

The [Artel MVS] simplified and streamlined our QC process…

Natalie Grow

Bristol-Meyers Squibb

The MVS system has been vital to our lab operations.

Hyun-Wu Lee

Canada's Michael Smith Genome Sciences Centre

We’re here to help

If you have any questions about Cell Line Development or are interested in learning more, please ask!

Contact Us

Marta Rucka Ph.D.


Global Product Manager, VIPS PRO