3320 Single-Sample Micro Osmometer

Product Type: Osmometers

The Advanced® Model 3320 Micro-Osmometer is a single-sample osmometer designed to provide fast, accurate test results using a 20 µL sample. It combines proven freezing point technology with an elegant design that is both simple to operate and easy to maintain. It is ideally suited for routine osmolality testing in clinical diagnostic, pharmaceutical, and industrial laboratory settings.


Small sample size

Requires only a 20 µL sample and is perfectly suited for sample-limited applications

Easy to use

With features including one-step sampling, a menu-driven interface, automatic calibration, and onboard statistical analysis, the 3320 combines world-class performance with a user-friendly package

Fast and reliable test results

With a 60 second test time, the 3320 can quickly process samples and improve laboratory productivity with industry-leading accuracy and precision

Proven reliability

The 3320 system incorporates over 60 years of applied technology and expertise in the field of osmometry and is ideal for laboratories seeking greater control, minimal downtime, and higher productivity

Flexible system options

Select from an optional external printer and barcode scanner to customize the 3320 for your specific laboratory requirements

Versatile sample processing

The 3320 is ideally suited for analyzing complex aqueous mixtures including blood, serum, plasma, urine, cell cultures, drug formulations, and many other non-biological sample types

Freezing point technology

The industry preferred method for determining sample concentration because it accounts for ALL solutes in solution

Products & Supplies

Available Models

3320 Model 3320 Micro-Sample Osmometer

Osmometer Calibration Standards and Reference Solutions

3LA201 2000 mOsm Calibration Standard, 10x5 mL Ampules View
3MA029 Clinitrol™ 290 Reference Solution, 10x2 mL Ampules View
3MA005 50 mOsm Calibration Standard, 10x2 mL View
3MA085 850 mOsm Calibration Standard, 10x2 mL View
3LA028 Osmolality Linearity Set 100-2,000 mOsm 5x2x5 mL View

Osmometer Control Solutions

3MA028 Protinol® 3-Level Osmometer Control, 3x3x3 mL View
3LA085 Renol™ 2-Level Osmometer Control, 2x4x3 mL View

Supplies and Accessories

210555_EU Thermal Printer (230 VAC power supply)
210555_NA Thermal Printer (100-120 VAC power supply)
3325 User's Guide
3325SM Service Manual
3D3835 Thermal Printer Paper, 5/pkg
330016 Bar Code Scanner
3M0825 Ease-Eject 20-Microliter Sampler
3M0827 Sampler Calibration Key
3M0828 Sampler Plunger Wire, 2/pkg
3MA800 Sample Tips and Chamber Cleaners, 500/box


ControLine™ ProductsDownload (pdf)
Effects of Hemolysis, Icterus, and Lipemia on Serum Osmolality Results using the Advanced Model 3250 Single-Sample OsmometerDownload (pdf)
Osmometry – The Rational Basis for use of an Under-appreciated Diagnostic ToolDownload (pdf)
Osmometry RevisitedDownload (pdf)
Performance Characteristics of the Advanced Model 3320 OsmometerDownload (pdf)
Performance Evaluation of Commercially Available Osmometer Control SolutionsDownload (pdf)
Refrigerated and Room Temperature Storage Stability of Serum Osmolality MeasurementsDownload (pdf)
Refrigerated and Room Temperature Storage Stability of Urine Osmolality MeasurementsDownload (pdf)
Sports Hydration: ’07Download (pdf)
The Physical Chemistry, Theory and Technique of Freezing Point DeterminationsDownload (pdf)
Using Osmometry for Water – Electrolyte Balance Experiments in the Instructional LaboratoryDownload (pdf)
Utilization of Controls, Materials, and Osmometry in a Clinical Setting Offers Quality BenefitsDownload (pdf)
Water Metabolism: Made EasierDownload (pdf)