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Theory and Benefits of Freezing Point Depression Osmometry

Introduction and Basic Principles
Advanced® Osmometers use the industry-preferred freezing point method to determine the osmolality of an aqueous-based solution. When a solute (particles) is dissolved in a solvent (water), the freezing point of that solution is lower than that of the solvent alone. As more solute is added, the freezing point decreases further. By precisely measuring the freezing point of the solution, the osmolality, or concentration, can be determined. Freezing point measurement is non-specific; that is, it will not tell you what the particle is, nor will it tell you the size or shape of the particle. The freezing point depends only on the number of particles in solution.


Practical Applications of Freezing Point Depression

Freezing Point Thermodynamics